Ericsson U B, Bjerre I, Forsgren M, Ivarsson S A
Epilepsia. 1985 Nov-Dec;26(6):594-6. doi: 10.1111/j.1528-1157.1985.tb05697.x.
Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid-stimulating hormone (TSH) and thyroglobulin (Tg) were measured in 24 patients with epilepsy taking anticonvulsants (either phenytoin, carbamazepine, or valproic acid as single treatment) and in a control group of 28 patients with scoliosis but without thyroid disease. The T4 as well as the TSH concentrations were depressed in patients on phenytoin or carbamazepine treatment. The T3 concentration was increased in the patients on carbamazepine or valproic acid treatment, whereas the Tg levels were unaffected by all three drugs. Thus, a slight depression of the TSH concentration within the normal range does not influence the Tg release. The lack of change in the Tg concentration also speaks against a direct effect of the antiepileptic drugs on the thyroid gland.
对24例服用抗惊厥药（苯妥英、卡马西平或丙戊酸单药治疗）的癫痫患者以及28例患有脊柱侧弯但无甲状腺疾病的对照组患者，测定血清总三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）和甲状腺球蛋白（Tg）的浓度。接受苯妥英或卡马西平治疗的患者T4以及TSH浓度降低。接受卡马西平或丙戊酸治疗的患者T3浓度升高，而Tg水平不受这三种药物的影响。因此，正常范围内TSH浓度的轻微降低不会影响Tg的释放。Tg浓度缺乏变化也表明抗癫痫药物对甲状腺无直接作用。
