Danysz W, Jonsson G, Mohammed A K, Archer T
Eur J Pharmacol. 1985 Oct 22;116(3):331-3. doi: 10.1016/0014-2999(85)90172-4.
The degree of hindlimb extension reflex (ER), post-decapitation reflex (PDR) and noradrenaline (NA) depletion was measured under various treatment regimens involving the neurotoxins DSP4 and 6-OHDA. Neither neonatal 6-OHDA treatment, direct application of 6-OHDA to the locus coeruleus nor DSP4 treatment produced a blockade of ER that could be associated with the loss of PDR and the spinal NA depletion, whereas intrathecal 6-OHDA treatment caused a strong loss of both ER and PDR related to severe spinal NA depletion. No correlation was obtained between the ER and PDR in a large number of DSP4-treated rats.
在涉及神经毒素DSP4和6-羟基多巴胺（6-OHDA）的各种治疗方案下，测量了后肢伸展反射（ER）、断头后反射（PDR）的程度以及去甲肾上腺素（NA）的消耗情况。无论是新生期6-OHDA治疗、将6-OHDA直接应用于蓝斑，还是DSP4治疗，均未产生与PDR丧失和脊髓NA消耗相关的ER阻断，而鞘内注射6-OHDA治疗则导致与严重脊髓NA消耗相关的ER和PDR均严重丧失。在大量接受DSP4治疗的大鼠中，未发现ER与PDR之间存在相关性。
