Hlongwa Khanyisile, Kolade Olumayowa, Alnabulsi Abdulilah, Steyn Rachelle, Brink Anita, Prasad Vikas, More Stuart
Department of Nuclear Medicine, Red Cross Children's Hospital and Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Clinical Theranostics, Department of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, United States.
Front Nucl Med. 2023 Aug 3;3:1193880. doi: 10.3389/fnume.2023.1193880. eCollection 2023.
Neuroendocrine tumors (NETs) are not commonly diagnosed in children. Metastatic NETs tend to have poor outcomes, and this is seen in adult and pediatric populations. The role of somatostatin receptor imaging using [Ga]Ga-DOTA-TATE for imaging and peptide receptor radionuclide therapy (PRRT) with [Lu]Lu-DOTA-TATE in children is currently not well established. The guidelines for treating pediatric neuroendocrine tumors are still lacking. Extensive trials have been conducted in adult patients and have demonstrated improved survival in metastatic NETs with PRRT using [Lu]Lu-DOTA-TATE. We present two pediatric patients with metastatic NETs who were imaged with [Ga]Ga-DOTA-TATE PET/CT and treated with [Lu]Lu-DOTA-TATE therapy.
神经内分泌肿瘤（NETs）在儿童中并不常见。转移性NETs往往预后较差，在成人和儿童人群中均是如此。目前，使用[Ga]镓 - DOTA - TATE进行生长抑素受体成像以及使用[Lu]镥 - DOTA - TATE进行肽受体放射性核素治疗（PRRT）在儿童中的作用尚未明确。治疗儿童神经内分泌肿瘤的指南仍很缺乏。在成年患者中已经进行了广泛的试验，结果表明使用[Lu]镥 - DOTA - TATE进行PRRT可提高转移性NETs患者的生存率。我们报告了两名患有转移性NETs的儿科患者，他们接受了[Ga]镓 - DOTA - TATE PET/CT成像，并接受了[Lu]镥 - DOTA - TATE治疗。
