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噬菌体疗法：一种对抗多重耐药病原体的新方法。

Phage therapy: A novel approach against multidrug-resistant pathogens.

作者信息

Kapoor Arushi, Mudaliar Samriti Balaji, Bhat Vyasraj G, Chakraborty Ishita, Prasad Alevoor Srinivas Bharath, Mazumder Nirmal

机构信息

Robert R Mcormick School of Engineering and Applied Science, Northwestern University, Illinois, USA.

Department of Public Health Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104 India.

出版信息

3 Biotech. 2024 Oct;14(10):256. doi: 10.1007/s13205-024-04101-8. Epub 2024 Sep 30.

DOI:10.1007/s13205-024-04101-8
PMID:39355200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11442959/
Abstract

The rapid rise of multidrug-resistant (MDR) organisms has created a critical need for alternative treatment options. Phage therapy is gaining attention as an effective way to fight bacterial infections by using lytic bacteriophages to specifically target and kill harmful bacteria. This review discusses several phage therapeutic options and emphasizes new developments in phage biology. Phage treatment has proven to be successful against MDR bacteria, as evidenced by multiple human clinical trials that indicate favorable results in treating a range of diseases caused by these pathogens. Despite these promising results, challenges such as phage resistance, regulatory hurdles, and the need for standardized treatment protocols remain. To effectively combat MDR bacterial infections, future research must focus on enhancing phage effectiveness, guaranteeing safety for human usage and incorporating phage therapy into clinical practice.

摘要

多重耐药（MDR）微生物的迅速增加使得人们迫切需要其他治疗选择。噬菌体疗法作为一种通过使用裂解性噬菌体特异性靶向并杀死有害细菌来对抗细菌感染的有效方法，正日益受到关注。本综述讨论了几种噬菌体治疗方案，并强调了噬菌体生物学的新进展。多项人体临床试验表明，噬菌体治疗在治疗由这些病原体引起的一系列疾病方面取得了良好效果，这证明噬菌体治疗对多重耐药细菌是成功的。尽管取得了这些有前景的结果，但仍存在诸如噬菌体耐药性、监管障碍以及对标准化治疗方案的需求等挑战。为了有效对抗多重耐药细菌感染，未来的研究必须专注于提高噬菌体的有效性、确保其对人类使用的安全性，并将噬菌体疗法纳入临床实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d5c/11442959/dcba030dd38d/13205_2024_4101_Fig10_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d5c/11442959/3ccfa9ead6fe/13205_2024_4101_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d5c/11442959/ad7529847b1d/13205_2024_4101_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d5c/11442959/f9126bb94530/13205_2024_4101_Fig8_HTML.jpg
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