Diezel W, Günther W, Meffert H, Thoss K, Sönnichsen N
Dermatol Monatsschr. 1979 Sep;165(9):629-33.
Immune complexes isolated from sera of psoriatic patients and healthy controls show an identical pattern in sodiumdodecylsulfate polyacrylamide gel electrophoresis. And so it seems to be unlikely that the increased provable serum immune complexes by psoriatics contain specific protein antigens.--Following to limited proteolysis of normal human epidermis, antibodies which solely are provable in sera of psoriatic patients could bind to proteolytic altered structures. For achieving a similar process in vivo, the following conditions are to be discussed: (1) an elevated concentration of certain autoantibodies in the sera of psoriatic patients and a temporary increased vessels permeability for antibodies, (2) the availability of structures in the epidermis of psoriatics with increased affintiy to certain antibodies. These structures may be produced by limited proteolysis or as a result of the disturbed differentiation of epidermal cells.
从银屑病患者和健康对照者血清中分离出的免疫复合物在十二烷基硫酸钠聚丙烯酰胺凝胶电泳中显示出相同的模式。因此，银屑病患者血清中可检测到的免疫复合物增加似乎不太可能含有特定的蛋白质抗原。——在对正常人表皮进行有限的蛋白水解后，仅在银屑病患者血清中可检测到的抗体能够与蛋白水解改变的结构结合。为了在体内实现类似的过程，需要讨论以下条件：（1）银屑病患者血清中某些自身抗体浓度升高，且抗体的血管通透性暂时增加；（2）银屑病患者表皮中存在对某些抗体亲和力增加的结构。这些结构可能是由有限的蛋白水解产生的，或者是表皮细胞分化紊乱的结果。
