Sun Liying, Ye Xuhui, Yu Junping, Wang Linlin, Wu Yan, Cui Jing, Dai Lihua
Intensive Care Unit, Shidong Hospital, Shanghai, People's Republic of China.
Int J Gen Med. 2024 Sep 27;17:4397-4405. doi: 10.2147/IJGM.S483064. eCollection 2024.
Previous studies have reported that lymphocyte-to-monocyte ratio (LMR) is associated with the prognosis of patients with acute ischemic stroke (AIS); however, the relationship between LMR and early neurological deterioration (END) in AIS patients has not been elucidated.
Patients were divided into two groups according to LMR by using receiver operating characteristic (ROC) curve analysis. Patients with END were confirmed as the National Institutes of Health Stroke Scale (NIHSS) increased ≥ 4 points between hospital days 0 and 5. Multivariate logistic regression analysis was used to analyze the factors independently related to END in patients with AIS.
In total, 202 patients diagnosed with AIS were enrolled in this retrospective study. Using ROC curve analysis, patients were divided into two groups according to LMR: low LMR group (LMR < 3.24, n = 95) and high LMR group (LMR ≥ 3.24, n = 107). The frequencies of END were significantly higher in the low LMR group compared to the high LMR group (41.05 vs.15.89%, p < 0.001). Multivariate logistic regression showed that age (OR = 1.03, 95% CI 1.01-1.06, p = 0.04), infarct volume (OR = 1.01, 95% CI 1.00-1.02, p = 0.001), neutrophil count (OR = 1.17, 95% CI 1.03-1.33, p = 0.018), and LMR (OR = 2.49, 95% CI 1.01-9.11, p = 0.018) were independently associated with END in AIS patients.
A peripheral LMR levels at admission were significantly associated with END and LMR < 3.24 is an independent predictive factor of END in patients with AIS.
既往研究报道淋巴细胞与单核细胞比值（LMR）与急性缺血性卒中（AIS）患者的预后相关；然而，AIS患者中LMR与早期神经功能恶化（END）之间的关系尚未阐明。
采用受试者工作特征（ROC）曲线分析，根据LMR将患者分为两组。END患者被定义为美国国立卫生研究院卒中量表（NIHSS）在住院第0天至第5天增加≥4分。采用多因素logistic回归分析AIS患者中与END独立相关的因素。
本回顾性研究共纳入202例诊断为AIS的患者。通过ROC曲线分析，根据LMR将患者分为两组：低LMR组（LMR<3.24，n=95）和高LMR组（LMR≥3.24，n=107）。低LMR组的END发生率显著高于高LMR组（41.05%对15.89%，p<0.001）。多因素logistic回归显示，年龄（OR=1.03，95%CI 1.01-1.06，p=0.04）、梗死体积（OR=1.01，95%CI 1.00-1.02，p=0.001）、中性粒细胞计数（OR=1.17，95%CI 1.03-1.33，p=0.018）和LMR（OR=2.49，95%CI 1.01-9.11，p=0.018）与AIS患者的END独立相关。
入院时外周血LMR水平与END显著相关，且LMR<3.24是AIS患者END的独立预测因素。
