新冠病毒疫苗接种后并发白塞病相关全葡萄膜炎：一例报告
Behcet's disease-related panuveitis following COVID-19 vaccination: A case report.
作者信息
Lin Rou-Ting, Liu Pei-Kang, Chang Chia-Wei, Cheng Kai-Chun, Chen Kuo-Jen, Chang Yo-Chen
机构信息
School of Medicine, College of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Department of Clinical Education and Training, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
出版信息
World J Radiol. 2024 Sep 28;16(9):460-465. doi: 10.4329/wjr.v16.i9.460.
BACKGROUND
Behcet's disease (BD) is an inflammatory disorder known for various symptoms, including oral and genital ulcers and ocular inflammation. Panuveitis, a severe eye condition, is rare as the first sign of BD.
CASE SUMMARY
We present an unusual case of a 30-year-old man who developed panuveitis after receiving the mRNA-based coronavirus disease 2019 (COVID-19) vaccine (Moderna). Laboratory tests ruled out infections, but he had a positive HLA-B51 result and a history of genital ulcer and oral ulcers, leading to a BD diagnosis. Treatment with corticosteroids improved his condition. Interestingly, he had another episode of panuveitis after the second mRNA vaccine dose, which also responded to corticosteroids.
CONCLUSION
This case highlights the rare onset of BD following mRNA COVID-19 vaccination, suggesting a potential link between these vaccines and BD's eye symptoms, emphasizing the importance of quick treatment in similar cases.
背景
白塞病（BD）是一种炎症性疾病，以多种症状为特征，包括口腔和生殖器溃疡以及眼部炎症。全葡萄膜炎是一种严重的眼部疾病，作为BD的首发症状较为罕见。
病例摘要
我们报告一例罕见病例，一名30岁男性在接种基于信使核糖核酸（mRNA）的2019冠状病毒病（COVID-19）疫苗（Moderna）后发生了全葡萄膜炎。实验室检查排除了感染，但他的人类白细胞抗原B51（HLA-B51）检测结果呈阳性，并有生殖器溃疡和口腔溃疡病史，最终诊断为BD。使用皮质类固醇进行治疗后病情有所改善。有趣的是，在接种第二剂mRNA疫苗后，他再次出现全葡萄膜炎，同样对皮质类固醇治疗有反应。
结论
该病例突出了接种mRNA COVID-19疫苗后BD罕见发病的情况，提示这些疫苗与BD眼部症状之间可能存在联系，强调了在类似病例中快速治疗的重要性。
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