• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

解读罕见病例：一例独特的口腔鳞状细胞癌透明细胞变体病例

Decoding the Rarity: A Unique Case of Clear-Cell Variant of Oral Squamous Cell Carcinoma.

作者信息

Paul Anwesha, Chatterjee Arunit, Chatterjee Rudra Prasad, Bagchi Sudeshna, Sultana Mehebuba, Sinha Sangeeta, Pal Mousumi, Das Sanjeet

机构信息

Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences & Research, Kolkata, IND.

出版信息

Cureus. 2024 Sep 1;16(9):e68389. doi: 10.7759/cureus.68389. eCollection 2024 Sep.

DOI:10.7759/cureus.68389
PMID:39355464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11444310/
Abstract

The clear-cell variant of oral squamous cell carcinoma is an extremely rare histological variant and an incompletely understood entity. Clear cell appearance in squamous cell carcinoma may be attributed to hydropic degeneration of neoplastic cells. We report a case of a 32-year-old male patient who presented with an ulceroproliferative growth in the left maxillary posterior region on the hard palate and gingiva, obliterating the buccal vestibule. Histopathologic examination revealed thick anastomosing strands of round to ovoid neoplastic cells with predominantly clear cytoplasm and marked cellular and nuclear pleomorphism infiltrating into the fibro-cellular connective tissue stroma. Special staining and immunohistochemistry (IHC) were performed to rule out the differentials of clear-cell variants of different sites such as salivary gland, odontogenic origin, and metastatic tumors. The clear cells were negative for periodic acid Schiff (PAS) and mucicarmine. The malignant clear cells showed positive reactions with IHC markers pan-cytokeratin and P63 and yielded negative results for S100 and CD10, confirming the diagnosis as a clear-cell variant of oral squamous cell carcinoma. We emphasize the importance of prompt and comprehensive diagnostic work-up to identify this rare, aggressive, and possibly fatal neoplasm.

摘要

口腔鳞状细胞癌的透明细胞变体是一种极为罕见的组织学变体，其本质尚未完全明了。鳞状细胞癌中出现透明细胞现象可能归因于肿瘤细胞的水样变性。我们报告一例32岁男性患者，其左上颌后部硬腭和牙龈处出现溃疡性增生，致使颊前庭消失。组织病理学检查显示，有厚的相互吻合的条索状圆形至卵圆形肿瘤细胞，其细胞质主要为透明状，细胞和细胞核具有明显多形性，浸润至纤维细胞性结缔组织基质中。进行了特殊染色和免疫组织化学（IHC）检查，以排除不同部位透明细胞变体的鉴别诊断，如涎腺、牙源性起源和转移性肿瘤。透明细胞对过碘酸希夫（PAS）和黏液卡红染色呈阴性。恶性透明细胞对免疫组织化学标志物泛细胞角蛋白和P63呈阳性反应，而对S100和CD10呈阴性结果，确诊为口腔鳞状细胞癌的透明细胞变体。我们强调及时进行全面诊断检查对于识别这种罕见、侵袭性且可能致命的肿瘤的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/a07567259d55/cureus-0016-00000068389-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/1eb097d6dabe/cureus-0016-00000068389-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/667f90a0e713/cureus-0016-00000068389-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/7d48f16242e5/cureus-0016-00000068389-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/ec7f1e043eea/cureus-0016-00000068389-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/2e435d1cc23a/cureus-0016-00000068389-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/16c737e4379c/cureus-0016-00000068389-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/2cac88c5fefd/cureus-0016-00000068389-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/c220fa815e5f/cureus-0016-00000068389-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/ae1588169618/cureus-0016-00000068389-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/c63fd35f93bb/cureus-0016-00000068389-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/a07567259d55/cureus-0016-00000068389-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/1eb097d6dabe/cureus-0016-00000068389-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/667f90a0e713/cureus-0016-00000068389-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/7d48f16242e5/cureus-0016-00000068389-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/ec7f1e043eea/cureus-0016-00000068389-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/2e435d1cc23a/cureus-0016-00000068389-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/16c737e4379c/cureus-0016-00000068389-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/2cac88c5fefd/cureus-0016-00000068389-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/c220fa815e5f/cureus-0016-00000068389-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/ae1588169618/cureus-0016-00000068389-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/c63fd35f93bb/cureus-0016-00000068389-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6185/11444310/a07567259d55/cureus-0016-00000068389-i11.jpg

相似文献

1
Decoding the Rarity: A Unique Case of Clear-Cell Variant of Oral Squamous Cell Carcinoma.解读罕见病例：一例独特的口腔鳞状细胞癌透明细胞变体病例
Cureus. 2024 Sep 1;16(9):e68389. doi: 10.7759/cureus.68389. eCollection 2024 Sep.
2
Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review.上颌牙龈的透明细胞鳞状细胞癌与 PIK3CA 和 HRAS 突变相关：病例报告及文献复习。
Head Neck Pathol. 2023 Dec;17(4):1026-1033. doi: 10.1007/s12105-023-01580-8. Epub 2023 Sep 21.
3
Clear cell variant of oral squamous cell carcinoma: case report and review.口腔鳞状细胞癌透明细胞变体：病例报告与文献复习
Autops Case Rep. 2022 Jul 18;12:e2021388. doi: 10.4322/acr.2021.388. eCollection 2022.
4
A rare case report of clear cell variant of oral squamous cell carcinoma.一例口腔鳞状细胞癌透明细胞变体的罕见病例报告。
J Clin Diagn Res. 2014 Dec;8(12):QD07-9. doi: 10.7860/JCDR/2014/11536.5339. Epub 2014 Dec 5.
5
Do Clear Cell Changes in Oral Squamous Cell Carcinoma Warrant It Being Recognised as a Variant?口腔鳞状细胞癌中的透明细胞改变是否足以使其被认定为一种变体？
Cureus. 2022 May 16;14(5):e25057. doi: 10.7759/cureus.25057. eCollection 2022 May.
6
Clear cell oral squamous cell carcinoma as a diagnostic conundrum: report of 2 rare cases.透明细胞口腔鳞状细胞癌作为一种诊断难题：2 例罕见病例报告。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2024 May;137(5):e83-e90. doi: 10.1016/j.oooo.2023.12.784. Epub 2023 Dec 19.
7
Clear-cell variant of oral squamous cell carcinoma: A rare entity.口腔鳞状细胞癌的透明细胞变体：一种罕见的实体。
J Oral Maxillofac Pathol. 2021 Mar;25(Suppl 1):S22-S26. doi: 10.4103/jomfp.JOMFP_295_20. Epub 2021 Mar 19.
8
A rare case of clear cell variant of oral squamous cell carcinoma.一例罕见的口腔鳞状细胞癌透明细胞变异型病例。
J Nat Sci Biol Med. 2015 Jan-Jun;6(1):245-7. doi: 10.4103/0976-9668.149209.
9
Clear-cell variant of squamous cell carcinoma in maxilla as primary lesion: A rare case.上颌骨原发性鳞状细胞癌透明细胞变异型：1例罕见病例。
J Oral Maxillofac Pathol. 2017 Sep-Dec;21(3):425-428. doi: 10.4103/jomfp.JOMFP_180_16.
10
Clear-cell Variant of Mucoepidermoid Carcinoma Presenting as a Palatal Mass in a 10-Year-old Boy.10 岁男孩腭部肿块：黏液表皮样癌透明细胞变异型。
Anticancer Res. 2023 Feb;43(2):939-942. doi: 10.21873/anticanres.16238.

本文引用的文献

1
Comprehensive Analysis of Oral Squamous Cell Carcinomas: Clinical, Epidemiological, and Histopathological Insights With a Focus on Prognostic Factors and Survival Time.口腔鳞状细胞癌的综合分析：临床、流行病学和组织病理学见解，重点关注预后因素和生存时间
Cureus. 2024 Feb 18;16(2):e54394. doi: 10.7759/cureus.54394. eCollection 2024 Feb.
2
Clear cell oral squamous cell carcinoma as a diagnostic conundrum: report of 2 rare cases.透明细胞口腔鳞状细胞癌作为一种诊断难题：2 例罕见病例报告。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2024 May;137(5):e83-e90. doi: 10.1016/j.oooo.2023.12.784. Epub 2023 Dec 19.
3
Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review.
上颌牙龈的透明细胞鳞状细胞癌与 PIK3CA 和 HRAS 突变相关：病例报告及文献复习。
Head Neck Pathol. 2023 Dec;17(4):1026-1033. doi: 10.1007/s12105-023-01580-8. Epub 2023 Sep 21.
4
Oral metastatic clear-cell tumours: To and fro: Unusual case reports.口腔转移性透明细胞肿瘤：来来回回：罕见病例报告。
J Oral Maxillofac Pathol. 2022 Apr-Jun;26(2):268-272. doi: 10.4103/jomfp.jomfp_104_21. Epub 2022 Jun 28.
5
Clear cell variant of oral squamous cell carcinoma: case report and review.口腔鳞状细胞癌透明细胞变体：病例报告与文献复习
Autops Case Rep. 2022 Jul 18;12:e2021388. doi: 10.4322/acr.2021.388. eCollection 2022.
6
Do Clear Cell Changes in Oral Squamous Cell Carcinoma Warrant It Being Recognised as a Variant?口腔鳞状细胞癌中的透明细胞改变是否足以使其被认定为一种变体？
Cureus. 2022 May 16;14(5):e25057. doi: 10.7759/cureus.25057. eCollection 2022 May.
7
Clear cell squamous cell carcinoma of the tongue exhibits characteristics as an undifferentiated squamous cell carcinoma.舌透明细胞鳞状细胞癌表现为未分化鳞状细胞癌的特征。
Pathol Res Pract. 2022 Jul;235:153909. doi: 10.1016/j.prp.2022.153909. Epub 2022 Apr 26.
8
Clear-cell variant of oral squamous cell carcinoma: A rare entity.口腔鳞状细胞癌的透明细胞变体：一种罕见的实体。
J Oral Maxillofac Pathol. 2021 Mar;25(Suppl 1):S22-S26. doi: 10.4103/jomfp.JOMFP_295_20. Epub 2021 Mar 19.
9
Clear cell variant of Oral Squamous cell carcinoma.口腔鳞状细胞癌的透明细胞变体
J Exp Ther Oncol. 2019 Dec;13(2):159-163.
10
Clear-cell variant of squamous cell carcinoma in maxilla as primary lesion: A rare case.上颌骨原发性鳞状细胞癌透明细胞变异型：1例罕见病例。
J Oral Maxillofac Pathol. 2017 Sep-Dec;21(3):425-428. doi: 10.4103/jomfp.JOMFP_180_16.