Keenan Kate, Walton Sarah, Mbayiwa Kimberley, Akande Lara, Cherian Anna, Ciaccio Christina, Tare Ilaria
Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
Department of Pediatrics, The University of Chicago, Chicago, IL, USA.
J Asthma Allergy. 2024 Sep 26;17:929-933. doi: 10.2147/JAA.S474009. eCollection 2024.
Black American children are at higher risk for developing asthma than White children. Identifying potential scalable preventive interventions that can reduce the racial disparities in asthma prevalence and associated morbidity and mortality are needed. We leveraged data from an RCT of prenatal supplementation with docosahexaenoic acid (DHA) in Black American women, to explore whether prenatal fatty acid supplementation is associated with offspring wheeze and asthma.
Data were from the Nutrition and Pregnancy Study (NAPS), a double-blind RCT of prenatal DHA supplementation in Black women targeting stress regulation during pregnancy. A subset of mothers (n = 83) completed a standardized questionnaire on offspring wheeze and asthma when children were between 0.5 and 5.5 years of age. DHA levels were measured from venous blood and reported as percent of total fatty acids.
Of the 83 mothers providing data on child wheeze and asthma, 57 (68.7%) had been randomized to active DHA and 26 (31.3%) to placebo. Mothers and research staff were blind to group assignment. Comparison at the group assignment level yielded a relative reduction of 32% in the rate of wheeze or asthma among offspring of mothers assigned to active DHA compared to offspring of mothers assigned to placebo (OR = 1.6 [95% CI = 0.50-5.09], p = 0.426). DHA levels measured at 25-29 and 33-37 weeks of gestation differed as a function of offspring wheeze or asthma (t = 2.21, p = 0.015 and t = 2.54, p = 0.007, respectively).
These preliminary data suggest that increasing prenatal levels of DHA could be considered as a potential prevention for asthma in Black American children.
美国黑人儿童患哮喘的风险高于白人儿童。需要确定可扩大规模的潜在预防干预措施，以减少哮喘患病率及相关发病率和死亡率方面的种族差异。我们利用了一项针对美国黑人女性进行的二十二碳六烯酸（DHA）产前补充随机对照试验的数据，以探讨产前脂肪酸补充与后代喘息和哮喘是否相关。
数据来自营养与妊娠研究（NAPS），这是一项针对黑人女性进行的产前DHA补充双盲随机对照试验，旨在调节孕期压力。一部分母亲（n = 83）在孩子0.5至5.5岁时完成了一份关于后代喘息和哮喘的标准化问卷。从静脉血中测量DHA水平，并报告为总脂肪酸的百分比。
在提供孩子喘息和哮喘数据的83位母亲中，57位（68.7%）被随机分配到活性DHA组，26位（31.3%）被分配到安慰剂组。母亲和研究人员对分组情况不知情。在分组层面进行比较时，与分配到安慰剂组的母亲的后代相比，分配到活性DHA组的母亲的后代喘息或哮喘发生率相对降低了32%（OR = 1.6 [95% CI = 0.50 - 5.09]，p = 0.426）。在妊娠25 - 29周和33 - 37周时测量的DHA水平因后代喘息或哮喘情况而有所不同（分别为t = 2.21，p = 0.015和t = 2.54，p = 0.007）。
这些初步数据表明，提高产前DHA水平可被视为预防美国黑人儿童哮喘的一种潜在措施。
