Le Tan Minh, Nguyen Hong Duc Thi, Cho Junghwan, Park Nora Jee-Young, Han Hyung Soo, Chong Gun Oh, Seo Incheol
Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu 41944, Republic of Korea.
Clinical Omics Institute, Kyungpook National University, Daegu 41405, Republic of Korea.
Oncol Lett. 2024 Sep 19;28(6):556. doi: 10.3892/ol.2024.14689. eCollection 2024 Dec.
Ovarian cancer (OC) presents a global health challenge, with well-documented genetic aspects. However, to the best of our knowledge, the role of human papillomavirus (HPV) types 16 and 18 in OC remains unclear. The present meta-analysis assessed the prevalence of HPV in OC across 43 studies and included a comparative meta-analysis of 19 case-control studies to determine the association of HPV with OC risk. Subgroup analyses were performed based on geographic regions and histopathological types to explore heterogeneity, and publication bias was evaluated using funnel plots and statistical tests of asymmetry. The pooled prevalence of HPV was found to be 10% (95% CI, 5-18) and 7% (95% CI, 3-15) specifically for HPV 16/18. Case-control studies indicated an odds ratio (OR) of 4.92 (95% CI, 1.96-12.53) for HPV 16/18, with higher pooled prevalence rates of 17% for all HPV genotypes and 13% for HPV 16/18. Notably, Asian countries exhibited the highest HPV prevalence and OR in OC. These findings support the involvement of HPV, particularly HPV 16 and 18, in increasing the risk of OC, emphasizing the need for further research to confirm these associations and explore potential mechanisms.
卵巢癌（OC）是一项全球性的健康挑战，其遗传因素已有充分记录。然而，据我们所知，16型和18型人乳头瘤病毒（HPV）在卵巢癌中的作用仍不明确。本荟萃分析评估了43项研究中卵巢癌患者HPV的流行情况，并对19项病例对照研究进行了比较荟萃分析，以确定HPV与卵巢癌风险之间的关联。基于地理区域和组织病理学类型进行亚组分析以探索异质性，并使用漏斗图和不对称性统计检验评估发表偏倚。发现HPV的合并流行率为10%（95%CI，5-18），其中HPV 16/18的合并流行率为7%（95%CI，3-15）。病例对照研究表明，HPV 16/18的比值比（OR）为4.92（95%CI，1.96-12.53），所有HPV基因型的合并流行率较高，为17%，HPV 16/18为13%。值得注意的是，亚洲国家卵巢癌患者中HPV的流行率和OR最高。这些发现支持HPV，特别是HPV 16和18，参与增加卵巢癌风险，强调需要进一步研究以证实这些关联并探索潜在机制。
