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维生素 D——饮食推荐对健康的影响仍然很强吗?

Vitamin D-Do Diet Recommendations for Health Remain Strong?

机构信息

School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA.

Think Healthy Group, LLC, Washington, DC, USA.

出版信息

Curr Osteoporos Rep. 2024 Dec;22(6):523-535. doi: 10.1007/s11914-024-00893-z. Epub 2024 Oct 2.

Abstract

How will the scientific community and authoritative bodies define future nutritional requirements for vitamin D? At the International Symposium on Nutritional Aspects of Musculoskeletal Health, the authors debated the strength of current evidence for setting vitamin D intake recommendations from diet: the positive side of the strength of the evidence (PRO) suggests there is a physiological requirement for vitamin D and the opposing view (CON) that in light of negative results from large, recent trials, particularly those with fractures and bone health outcomes, we are left rudderless. Should we provide recommendations based on empiric treatment of vitamin D for most groups and conditions? It is becoming increasingly evident that vitamin D plays a role in many physiological functions and processes associated with long-term human health; however, to what extent are these benefits apparent beyond what is needed for adequate nutritional status, measured as serum 25-hydroxyvitamin D levels, for active calcium absorption? The meeting attendees voted for the PRO vs. CON position at the end of the session.

摘要

科学界和权威机构将如何定义未来维生素 D 的营养需求?在骨骼肌肉健康营养方面的国际研讨会上,作者们就从饮食中设定维生素 D 摄入量建议的现有证据的强度展开了辩论:证据的有利方面(PRO)表明,人体对维生素 D 有生理需求,而相反的观点(CON)则认为,鉴于最近大型试验,特别是与骨折和骨骼健康结果相关的试验的负面结果,我们已经失去了方向。我们是否应该根据大多数人群和情况下维生素 D 的经验性治疗提供建议?越来越明显的是,维生素 D 在许多与人类长期健康相关的生理功能和过程中发挥作用;然而,除了血清 25-羟维生素 D 水平足够的营养状态所必需的程度之外,这些益处还能在多大程度上显现出来,以促进钙的主动吸收?与会者在会议结束时对 PRO 与 CON 的立场进行了投票。

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