Kılıçaslan Fethiye, Tan Aybike, Tanriverdi Zulkif
Department of Child and Adolescent Psychiatry, Harran University, Faculty of Medicine, Şanlıurfa, Türkiye.
Department of Cardiology, Harran University, Faculty of Medicine, Şanlıurfa, Türkiye.
J Atten Disord. 2025 Feb;29(3):165-173. doi: 10.1177/10870547241288353. Epub 2024 Oct 2.
Conflicting findings exist regarding the link between attention deficit hyperactivity disorder (ADHD) and cardiovascular diseases. This study aimed to evaluate the frontal QRS-T (fQRS-T) angle and its correlation with symptom severity in children diagnosed with ADHD.
The study population consisted of 172 patients diagnosed with ADHD (120 drug naive and 52 drug positive) and 82 healthy controls. ADHD symptoms were assessed using the Atilla Turgay DSM-IV-Based Screening and Assessment Scale for Disruptive Conduct Disorders (T-DSM-IV-Scale). The fQRS-T angle and corrected QT (QTc) interval were obtained from the automated reports of 12-lead electrocardiography device for each patient.
QTc interval and fQRS-T angle were significantly different among the groups. Post hoc analyses showed that QTc interval and fQRS-T angle of ADHD drug naive and ADHD drug positive patients were significantly higher than the healthy control groups. However, there was no significant difference between drug naive and drug positive patients regarding QTc interval and fQRS-T angle. Both QTc interval and fQRS-T angle showed positive correlations with the severity of ADHD symptoms (r = 0.263, = .001 and r = 0.175, = .023 respectively).
We found that fQRS-T angle was significantly wider in children with ADHD. Therefore, we suggest that fQRS-T angle may help in cardiovascular risk assessment in children with ADHD.
关于注意力缺陷多动障碍（ADHD）与心血管疾病之间的联系，存在相互矛盾的研究结果。本研究旨在评估额面QRS-T（fQRS-T）角及其与ADHD诊断儿童症状严重程度的相关性。
研究人群包括172例被诊断为ADHD的患者（120例未用药和52例用药）以及82名健康对照。使用基于阿提拉·图尔盖DSM-IV的破坏性行为障碍筛查和评估量表（T-DSM-IV量表）评估ADHD症状。从每位患者的12导联心电图设备自动报告中获取fQRS-T角和校正QT（QTc）间期。
各组间QTc间期和fQRS-T角存在显著差异。事后分析表明，未用药和用药的ADHD患者的QTc间期和fQRS-T角显著高于健康对照组。然而，未用药和用药患者在QTc间期和fQRS-T角方面无显著差异。QTc间期和fQRS-T角均与ADHD症状严重程度呈正相关（分别为r = 0.263，P = 0.001和r = 0.175，P = 0.023）。
我们发现ADHD儿童的fQRS-T角明显更宽。因此，我们建议fQRS-T角可能有助于ADHD儿童的心血管风险评估。
