Department of Otolaryngology Head and Neck Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China.
Department of Neurosurgery, The Fourth People's Hospital of Jinan, Jinan, Shandong Province, China.
Acta Otolaryngol. 2024 Sep;144(9):495-502. doi: 10.1080/00016489.2024.2404614. Epub 2024 Oct 2.
It has been shown that there is a link between thyroid-related diseases and hearing loss.
The purpose of this study is to investigate the relationship between thyroid-related diseases and hearing loss by conducting a meta-analysis.
A thorough search was carried out in the following electronic databases: PubMed, Cochrane Library, Embase, Web of Science, Google Scholar, Semantic Scholar, and ResearchRabbit. The chi-square test and the index examined the research's heterogeneity. A funnel plot and the Eger test were used to examine publication-biased effects.
A total of 48,507 individuals (6482 hypothyroid patients, 4162 hearing loss patients, and 37863 controls) were included in this meta-analysis of 18 research. Individuals with hypothyroidism had a 1.69-fold increased risk of hearing loss compared to those without the condition (OR: 1.69; 95% CI: 1.11-2.57, < 0.001). among hypothyroidism, the prevalence of hearing loss was 24% (EC: 0.24; 95% CI: 0.11-0.39, = 0.00), while among hearing-impaired individuals, the prevalence of hypothyroidism was 7% (EC: 0.21; 95% CI: 0.07-0.40).
This study demonstrated how thyroid dysfunction can raise the chance of hearing loss. To completely comprehend the underlying mechanisms and create efficient treatments for this illness, more study is required.
已经证明甲状腺相关疾病与听力损失之间存在关联。
本研究旨在通过进行荟萃分析来探究甲状腺相关疾病与听力损失之间的关系。
在以下电子数据库中进行了全面搜索：PubMed、Cochrane Library、Embase、Web of Science、Google Scholar、Semantic Scholar 和 ResearchRabbit。卡方检验和 I ² 指数用于评估研究的异质性。漏斗图和 Eger 检验用于评估发表偏倚效应。
这项荟萃分析纳入了 18 项研究中的 48507 名个体（6482 名甲状腺功能减退症患者、4162 名听力损失患者和 37863 名对照者）。与无甲状腺疾病的个体相比，甲状腺功能减退症患者发生听力损失的风险增加了 1.69 倍（OR：1.69；95%CI：1.11-2.57， < 0.001）。在甲状腺功能减退症患者中，听力损失的患病率为 24%（EC：0.24；95%CI：0.11-0.39， = 0.00），而在听力受损个体中，甲状腺功能减退症的患病率为 7%（EC：0.21；95%CI：0.07-0.40）。
本研究表明甲状腺功能障碍如何增加听力损失的风险。需要进一步研究以充分了解潜在机制并为这种疾病制定有效的治疗方法。
