Shrestha Mandira, Chimoriya Romila, Dhungel Amrit, Koirala Sujit, Bhatta Rohit, Basnet Bijay
Nepal Medical college and teaching hospital, Jorpati, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2024 Mar 31;62(272):264-268. doi: 10.31729/jnma.8554.
Post infectious glomerulonephritis remains the most common cause leading to the majority of hospital admissions in children of developing countries like ours. The aim of our study was to find the prevalence of post infectious glomerulonephritis, study the clinical profile, biochemical changes and its complication in children admitted in a tertiary care hospital of Nepal.
This descriptive cross-sectional study of children admitted at a tertiary care hospital was done from May 2020 till May 2023. A census sampling method was used and sample of 1554 children was taken. Detailed socio demographic data, clinical findings and laboratory investigations were done. Data analysis was done using SPSS software and the results obtained are shown in the form of frequencies along with percentages.
Among 1554 patients, the prevalence of acute post-infectious glomerulonephritis was found to be 63 (4.05%) (3.07-5.03 at 95% Confidence Interval). The mean age of the patients was 9.06±3.48 years. Antistreptolysin O titer was raised in 34 (54%) patients, while low serum C3 was observed in 39 (61.90%) patients with acute post-infectious glomerulonephritis.
Acute post-infectious glomerulonephritis (APIGN) remains a notable health concern in children, particularly in developing countries like Nepal. This highlights the need for ongoing surveillance, prevention strategies, and effective management protocols to address this burden effectively.
感染后肾小球肾炎仍然是导致像我们这样的发展中国家儿童大多数住院治疗的最常见原因。我们研究的目的是在尼泊尔一家三级护理医院收治的儿童中，找出感染后肾小球肾炎的患病率，研究其临床特征、生化变化及其并发症。
这项对一家三级护理医院收治儿童的描述性横断面研究于2020年5月至2023年5月进行。采用普查抽样方法，选取了1554名儿童作为样本。收集了详细的社会人口统计学数据、临床检查结果和实验室检查数据。使用SPSS软件进行数据分析，所得结果以频率和百分比的形式呈现。
在1554名患者中，急性感染后肾小球肾炎的患病率为63例（4.05%）（95%置信区间为3.07 - 5.03）。患者的平均年龄为9.06±3.48岁。34例（54%）患者抗链球菌溶血素O滴度升高，而39例（61.90%）急性感染后肾小球肾炎患者血清C3降低。
急性感染后肾小球肾炎（APIGN）在儿童中仍然是一个值得关注的健康问题，特别是在像尼泊尔这样的发展中国家。这凸显了持续监测、预防策略以及有效管理方案以有效应对这一负担的必要性。
