Clinical Assistant Professor in Paediatric Dentistry, Paediatric Dentistry, Faculty of Dentistry, the University of Hong Kong, Pokfulam, Hong Kong SAR, Hong Kong.
Tam Wah-Ching Professorship in Dental Science, Professor, Chair of Dental Public Health, Applied Oral Sciences & Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China.
J Dent. 2024 Nov;150:105356. doi: 10.1016/j.jdent.2024.105356. Epub 2024 Sep 30.
To compare the clinical efficacies of 5 % sodium fluoride varnish (NaFV) and glass-ionomer sealant (GIS) in preventing occlusal caries in primary second molars (PSMs).
A total of 736 children were recruited from 18 kindergartens and randomised into either Group 1- receiving NaFV quarterly, or Group 2 - single placement of GIS at baseline. Interventions were performed on 1431 and 1264 PSMs in Group 1 and Group 2, respectively. The primary outcome was the development of ICDAS≥4 dentine caries at the occlusal surfaces of PSMs.
A total of 736 children (383 in Group 1; 353 in Group 2) received the intervention. After 18-24 months, 479 children with 1764 PSMs were reviewed. Despite a low GIS retention rate of 2.4 % by 18-24 months, only 17.1 % of PSM in the GIS group developed caries into dentine. No significant difference was identified when compared to the proportion of PSMs with caries into dentine in the NaFV group (17.0 %). Regression analysis with GEE revealed that only baseline dft score and plaque level had a significant influence on development of ICDAS≥4 dentine caries in PSMs.
Quarterly-applied NaFV and a single placement of medium viscosity GIS have similar clinical efficacies in preventing occlusal caries among preschool children.
There is no significant difference between quarterly-applied NaFV and GIS in preventing occlusal caries at PSMs. Dental clinicians can choose to use either of these preventive methods after considering their own and parents' preferences, children's cooperation and other practical factors.
比较 5%氟化钠涂料（NaFV）和玻璃离子水门汀（GIS）在预防儿童第一恒磨牙（PSM）窝沟龋的临床疗效。
从 18 所幼儿园招募了 736 名儿童，随机分为 1 组（每 3 个月涂布 NaFV）和 2 组（基线时一次性涂布 GIS）。在第 1 组和第 2 组中，分别对 1431 个和 1264 个 PSM 进行了干预。主要结局是 PSM 窝沟表面 ICDAS≥4 牙本质龋的发生情况。
共有 736 名儿童（第 1 组 383 名；第 2 组 353 名）接受了干预。18-24 个月后，对 479 名儿童的 1764 个 PSM 进行了复查。尽管 GIS 在 18-24 个月时的保留率较低（2.4%），但 GIS 组中仅有 17.1%的 PSM 发展为牙本质龋。与 NaFV 组 PSM 发生牙本质龋的比例（17.0%）相比，差异无统计学意义。采用广义估计方程（GEE）的回归分析显示，仅基线 dft 评分和菌斑水平对 PSM 发生 ICDAS≥4 牙本质龋有显著影响。
每 3 个月涂布 NaFV 和一次性涂布中粘度 GIS 对预防学龄前儿童窝沟龋具有相似的临床疗效。
每 3 个月涂布 NaFV 和 GIS 在预防 PSM 窝沟龋方面无显著差异。在考虑到自身和家长的偏好、儿童的配合和其他实际因素后，牙科临床医生可以选择使用这两种预防方法中的任何一种。
