Cavallini Claudia, Olivi Elena, Tassinari Riccardo, Ventura Carlo
ELDOR Lab, Bologna, Italy.
ELDOR Lab, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
J Biol Chem. 2024 Nov;300(11):107847. doi: 10.1016/j.jbc.2024.107847. Epub 2024 Sep 30.
Signaling molecules exhibit mechanical oscillations, entailing precise vibrational directionalities. These steering signatures have profound functional implications and are intimately connected with the onset of molecular electric oscillations and biophoton emission. We discuss biophotonic activity as a form of endogenous photobiomodulation, orchestrating the mechano-sensing/-transduction in signaling players. We focus on exogenous photobiomodulation in the form of pulsed wave modulation of selected light wavelengths to direct endogenous biophotonic activity and molecular cellular dynamics. We highlight the relevance of this strategy to target and reprogram the developmental potential of tissue-resident stem cells in damaged tissues, affording precision regenerative medicine without the need for cell or tissue transplantation.
信号分子表现出机械振荡，具有精确的振动方向性。这些引导特征具有深远的功能意义，并与分子电振荡和生物光子发射的起始密切相关。我们将生物光子活性作为一种内源性光生物调节形式进行讨论，它协调信号传导参与者中的机械传感/转导。我们专注于以外源光生物调节的形式，即对选定光波长进行脉冲波调制，以引导内源性生物光子活性和分子细胞动力学。我们强调这种策略对于靶向和重新编程受损组织中组织驻留干细胞的发育潜能的相关性，从而提供无需细胞或组织移植的精准再生医学。
