Furkalo N K, Ivashchenko T I, Romanenko A I
Kardiologiia. 1985 Sep;25(9):55-9.
The effects of a variety of currently-used anti-anginal drugs on major hemorheologic parameters (blood viscosity in the 0.692-2348 s-1 variation rates range, plasma viscosity, erythrocyte and platelet function) and also the hemostatic system were examined in 100 chronic coronary patients during specific treatment courses. The nitrates, beta-blockers (alone or in combinations), cordaron and molsidomin were shown to produce positive effects on blood rheology. A relationship was demonstrated between physical stress tolerance and blood viscosity pattern in propranolol-treated coronary patients. It is suggested that positive hemorheologic effects of anti-anginal drugs may be an important constituent of their therapeutic action and, as such, provide an additional marker of their efficiency in coronary heart disease.
在100例慢性冠心病患者接受特定疗程治疗期间，研究了多种目前使用的抗心绞痛药物对主要血液流变学参数（0.692 - 2348 s-1变化率范围内的血液粘度、血浆粘度、红细胞和血小板功能）以及止血系统的影响。结果显示，硝酸盐类、β受体阻滞剂（单独使用或联合使用）、胺碘酮和吗多明对血液流变学产生了积极影响。在接受普萘洛尔治疗的冠心病患者中，身体应激耐受性与血液粘度模式之间存在关联。提示抗心绞痛药物的积极血液流变学效应可能是其治疗作用的重要组成部分，因此可作为其在冠心病治疗中疗效的额外指标。
