[Relation between therapeutic efficacy of antianginal preparations in patients with ischemic heart disease and their effect on the rheologic properties of blood].

The effects of a variety of currently-used anti-anginal drugs on major hemorheologic parameters (blood viscosity in the 0.692-2348 s-1 variation rates range, plasma viscosity, erythrocyte and platelet function) and also the hemostatic system were examined in 100 chronic coronary patients during specific treatment courses. The nitrates, beta-blockers (alone or in combinations), cordaron and molsidomin were shown to produce positive effects on blood rheology. A relationship was demonstrated between physical stress tolerance and blood viscosity pattern in propranolol-treated coronary patients. It is suggested that positive hemorheologic effects of anti-anginal drugs may be an important constituent of their therapeutic action and, as such, provide an additional marker of their efficiency in coronary heart disease.