Bolat Melda, Köse Dursun Ali, Akbaba Sema
Department of Property Protection and Security, Vocational School of Technical Sciences, Hitit University, Çorum, 19900, Türkiye.
Department of Chemistry, Faculty of Arts and Sciences, Hitit University, Çorum, 19040, Türkiye.
Biol Trace Elem Res. 2024 Oct 3. doi: 10.1007/s12011-024-04394-z.
The element boron forms a wide range of borate minerals with different properties. Borate minerals make it possible to design boron-containing molecules with new biological properties in terms of their chemical structure and properties. It is known that boron compounds have antioxidant, anti-inflammatory, anti-tumor and anti-cancer properties. This makes boron compounds important for the future development of boron chemotherapeutics, boron supplements and new drugs. Reliable scientific studies on boron compounds will facilitate the clear presentation of their functions in its biological applications and metabolism. In this study, boron monoester and boron diester structures were synthesized with salicylic acid ligand. To stabilize boron ester structures, Na, K, Mg, Ca cations were used as counter-ions. Structural properties of the synthesized substances, molecules obtained by crystallization/precipitation from aqueous solutions in solid state, elemental analysis, melting point determination, infrared spectroscopy analysis (FT-IR), thermal analysis (TGA/DTA), mass analysis (GC-MS) and single crystal analysis. Structural properties were tried to be explained by structure analysis (SC-XRD) methods. Additionally, the anticancer potential of boron salicylate esters against the MDA-MB-231 human breast adenocarcinoma cell line was examined. The K-B salicylate diester molecule was found to have the most potential potency with the lowest IC value against the MDA-MB-231 cell line. The anticancer potential of boron salicylate esters can be further investigated with other cancer models with the combination of anticancer drugs. It is also thought that the mechanism of action of these molecules may help reveal their further applications.
硼元素能形成多种具有不同性质的硼酸盐矿物。硼酸盐矿物因其化学结构和性质，使得设计具有新生物特性的含硼分子成为可能。众所周知，硼化合物具有抗氧化、抗炎、抗肿瘤和抗癌特性。这使得硼化合物对于硼化疗药物、硼补充剂和新药的未来发展具有重要意义。关于硼化合物的可靠科学研究将有助于清晰呈现其在生物应用和新陈代谢中的功能。在本研究中，用水杨酸配体合成了硼酸单酯和硼酸二酯结构。为稳定硼酸酯结构，使用了钠、钾、镁、钙阳离子作为抗衡离子。对合成物质进行了结构性质研究，这些物质是通过从水溶液中结晶/沉淀得到的固态分子，进行了元素分析、熔点测定、红外光谱分析（傅里叶变换红外光谱法）、热分析（热重分析/差示热分析）、质谱分析（气相色谱 - 质谱联用）和单晶分析。试图通过结构分析（单晶X射线衍射）方法解释结构性质。此外，还研究了水杨酸硼酸酯对MDA - MB - 231人乳腺腺癌细胞系的抗癌潜力。发现水杨酸硼酸二钾酯分子对MDA - MB - 231细胞系具有最显著的潜力，其IC值最低。水杨酸硼酸酯的抗癌潜力可与抗癌药物联合，通过其他癌症模型进一步研究。还认为这些分子的作用机制可能有助于揭示其进一步的应用。
