Bain V G, Bain G O
J Surg Oncol. 1985 Aug;29(4):227-30. doi: 10.1002/jso.2930290406.
The lymph node biopsies of 12 patients with lymphadenopathy due to reactive hyperplasia contained lymphocyte populations with increased percentages of B-cells and abnormal numbers of cells with single class surface immunoglobulins. Ten patients were followed for periods of 3-30 months: one developed a non-Hodgkin's lymphoma and one Hodgkin's disease. One other has persisting lymph node enlargement. Two patients had nonlymphoid malignancies. The other six remain well without lymphadenopathy. Twenty-five of 40 patients with reactive lymph node hyperplasia and normal kappa/lambda ratios followed for 9-36 months had a similar incidence of lymphoid malignancy and persistent lymph node enlargement. The follow-up data so far available do not support a hypothesis that reactive lymphoid hyperplasia with increased numbers of cells with single class surface immunoglobulin is associated with higher morbidity than reactive hyperplasia containing the usual polytypic lymphocyte populations.
12例因反应性增生导致淋巴结病患者的淋巴结活检显示，淋巴细胞群体中B细胞百分比增加，且具有单克隆表面免疫球蛋白的细胞数量异常。10例患者随访3 - 30个月：1例发展为非霍奇金淋巴瘤，1例发展为霍奇金病。另有1例持续存在淋巴结肿大。2例患者有非淋巴系统恶性肿瘤。其他6例情况良好，无淋巴结病。40例反应性淋巴结增生且kappa/lambda比值正常的患者随访9 - 36个月，其中25例有相似的淋巴系统恶性肿瘤发生率和持续淋巴结肿大情况。目前可得的随访数据不支持这样一种假设，即具有单克隆表面免疫球蛋白细胞数量增加的反应性淋巴增生比含有通常多克隆淋巴细胞群体的反应性增生具有更高的发病率。
