Peter Harrison Centre for Disability Sport, School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, UK.
Department of Exercise and Sport Science, St. Mary's University, San Antonio, Texas, USA.
Physiol Rep. 2024 Oct;12(19):e70073. doi: 10.14814/phy2.70073.
In persons with a spinal cord injury (SCI), resistance training using neuromuscular electrical stimulation (NMES-RT) increases lean mass in the lower limbs. However, whether protein supplementation in conjunction with NMES-RT further enhances this training effect is unknown. In this randomized controlled pilot trial, 15 individuals with chronic SCI engaged in 3 times/week NMES-RT, with (NMES+PRO, n = 8) or without protein supplementation (NMES, n = 7), for 12 weeks. Before and after the intervention, whole body and regional body composition (DXA) and fasting glucose and insulin concentrations were assessed in plasma. Adherence to the intervention components was ≥96%. Thigh lean mass was increased to a greater extent after NMES+PRO compared to NMES (0.3 (0.2, 0.4) kg; p < 0.001). Furthermore, fasting insulin concentration and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were decreased similarly in both groups (fasting insulin: 1 [-9, 11] pmol∙L; HOMA-IR: 0.1 [-0.3, 0.5] AU; both p ≥ 0.617). Twelve weeks of home-based NMES-RT increased thigh lean mass, an effect that was potentiated by protein supplementation. In combination with the excellent adherence and apparent improvement in cardiometabolic health outcomes, these findings support further investigation through a full-scale randomized controlled trial.
在脊髓损伤（SCI）患者中，使用神经肌肉电刺激（NMES-RT）的抗阻训练可增加下肢瘦体重。然而，尚不清楚与 NMES-RT 联合使用蛋白质补充剂是否能进一步增强这种训练效果。在这项随机对照初步试验中，15 名慢性 SCI 患者每周进行 3 次 NMES-RT，其中 8 人接受 NMES+PRO 治疗，7 人接受 NMES 治疗，共 12 周。在干预前后，通过双能 X 线吸收法（DXA）评估全身和局部身体成分以及空腹血糖和胰岛素浓度。干预成分的依从性≥96%。与 NMES 相比，NMES+PRO 使大腿瘦体重增加幅度更大（0.3（0.2，0.4）kg；p<0.001）。此外，两组的空腹胰岛素浓度和胰岛素抵抗稳态模型评估（HOMA-IR）均相似下降（空腹胰岛素：-9，11] pmol·L；HOMA-IR：-0.3，0.5] AU；均 p≥0.617）。12 周的家庭 NMES-RT 增加了大腿瘦体重，而蛋白质补充剂则增强了这种效果。结合良好的依从性和明显改善的心血管代谢健康结果，这些发现支持通过全面的随机对照试验进一步研究。
