Feller A, Uchida T, Rakela J
Liver. 1985 Oct;5(5):239-46. doi: 10.1111/j.1600-0676.1985.tb00244.x.
Of 20 patients with alcoholic liver cirrhosis and a superimposed episode of acute viral hepatitis, 12 developed hepatic encephalopathy or ascites or both. Four died of hepatic failure. Seventeen patients had received blood transfusions within 6 months before the acute hepatitic episode. Two patients were HBsAg-positive; the other 18 were presumptively diagnosed as having non-A, non-B hepatitis. However, hepatitis A virus infection was excluded in only three of the 18 patients. Histologic examination performed in 13 cases disclosed necrotizing inflammatory activity, which is commonly observed in acute viral hepatitis. The distinctive histologic feature was a meager regenerating activity. We conclude that patients with alcoholic cirrhosis complicated by acute viral hepatitis frequently develop hepatic failure and have a high fatality rate (20% in our series).
在20例酒精性肝硬化合并急性病毒性肝炎发作的患者中，12例出现肝性脑病或腹水或两者皆有。4例死于肝衰竭。17例患者在急性肝炎发作前6个月内接受过输血。2例患者HBsAg阳性；其他18例被推测诊断为非甲非乙型肝炎。然而，18例患者中仅3例排除了甲型肝炎病毒感染。13例患者进行了组织学检查，结果显示有坏死性炎症活动，这在急性病毒性肝炎中很常见。独特的组织学特征是再生活动微弱。我们得出结论，酒精性肝硬化合并急性病毒性肝炎的患者经常发生肝衰竭，且死亡率很高（在我们的系列研究中为20%）。
