Stern Nadide Mutlukoca, Mikalsen Lars Tore Gyland, Dueland Svein, Schulz Anselm, Line Pål-Dag, Stokke Caroline, Grut Harald
Department of Radiology, Vestre Viken Hospital Trust, Drammen, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Clin Physiol Funct Imaging. 2025 Jan;45(1):e12908. doi: 10.1111/cpf.12908. Epub 2024 Oct 2.
To determine whether heterogeneity in colorectal liver metastases (CRLM) F fluorodeoxyglucose [F]FDG distribution is predictive of disease-free survival (DFS) and overall survival (OS) following liver transplantation (LT) for unresectable CRLM.
The preoperative [F]FDG positron emission tomography/computed tomography examinations of all patients in the secondary cancer 1 and 2 studies were retrospectively assessed. Maximum standardized uptake value (SUV), metabolic tumour volume (MTV), and six texture heterogeneity parameters (joint entropy dissimilarity grey level variance size zone variance and zone percentage, and morphological feature convex deficiency) were obtained. DFS and OS for patients over and under the median value for each of these parameters were compared by using the Kaplan Meier method and log rank test.
Twenty-eight out of 40 patients who underwent LT for unresectable CRLM had liver metastases with uptake above liver background and were eligible for inclusion. Low MTV (p < 0.001) and dissimilarity (p = 0.016) were correlated to longer DFS. Low MTV (p < 0.001) and low values of the texture parameters dissimilarity (p = 0.038), joint entropy (p = 0.015) and zone percentage (p = 0.037) were significantly correlated to longer OS. SUV was not correlated to DFS and OS.
Although some texture parameters were able to significantly predict DFS and OS, MTV seems to be superior to predict both DFS and OS following LT for unresectable CRLM.
确定结直肠癌肝转移（CRLM）中氟脱氧葡萄糖[F]FDG分布的异质性是否可预测不可切除CRLM肝移植（LT）后的无病生存期（DFS）和总生存期（OS）。
回顾性评估继发性癌症1和2研究中所有患者的术前[F]FDG正电子发射断层扫描/计算机断层扫描检查。获得最大标准化摄取值（SUV）、代谢肿瘤体积（MTV）和六个纹理异质性参数（联合熵、差异度、灰度级方差、大小区域方差、区域百分比以及形态学特征凸度缺损）。使用Kaplan-Meier方法和对数秩检验比较这些参数中值以上和以下患者的DFS和OS。
40例因不可切除CRLM接受LT的患者中，28例肝转移灶摄取高于肝脏本底，符合纳入标准。低MTV（p<0.001）和差异度（p=0.016）与更长的DFS相关。低MTV（p<0.001）以及纹理参数差异度（p=0.038）、联合熵（p=0.015）和区域百分比（p=0.037）的低值与更长的OS显著相关。SUV与DFS和OS均无相关性。
尽管一些纹理参数能够显著预测DFS和OS，但对于不可切除CRLM的LT后DFS和OS的预测，MTV似乎更具优势。
