Viljanen Eliisa, Kholová Ivana, Chandra Ashish
Pathology, Fimlab Laboratories, Tampere, Finland.
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Cytopathology. 2025 Jan;36(1):12-22. doi: 10.1111/cyt.13450. Epub 2024 Oct 2.
The International System for Serous Fluid Cytopathology (TIS) is intended for reporting cytological specimens from serous cavities: pleural, abdominal and pericardial cavities. TIS is being adopted into practice in cytology laboratories worldwide. In this system, there are six diagnostic categories: non-diagnostic, negative for malignancy, atypia of undetermined significance, suspicious for malignancy, malignant-primary and malignant-secondary. Malignant-primary category almost always implies malignant mesothelioma and malignant-secondary usually refers to metastasis from carcinoma but also to involvement of serous cavity by haematolymphoid and other malignancies. When evaluating effusion cytological specimen adequacy, the factors that must be considered are sample volume, cellular content and cellular preservation. In the diagnostic analysis and interpretation, it is helpful to consider systematically all basic cytomorphological components in a sample. The basic components are architecture, cell populations, cell size, cytoplasm, nuclei and background elements. One important requirement for a successful evaluation of an effusion cytological specimen is sufficient clinical and radiological information in a referral. Clinical information may guide ancillary testing. In the present review, we provide a practical and educational approach to reporting serous effusion cytology based on the TIS.
国际浆液性液体细胞病理学系统（TIS）旨在报告来自浆膜腔（胸膜腔、腹腔和心包腔）的细胞学标本。TIS正在全球范围内的细胞学实验室中付诸实践。在这个系统中，有六个诊断类别：无法诊断、恶性阴性、意义未明的非典型性、恶性可疑、原发性恶性和继发性恶性。原发性恶性类别几乎总是意味着恶性间皮瘤，继发性恶性通常指癌转移，但也包括血液淋巴系统及其他恶性肿瘤累及浆膜腔。在评估积液细胞学标本的充分性时，必须考虑的因素有样本量、细胞成分和细胞保存情况。在诊断分析和解读过程中，系统地考虑样本中所有基本的细胞形态学成分会有所帮助。基本成分包括结构、细胞群体、细胞大小、细胞质、细胞核和背景成分。成功评估积液细胞学标本的一项重要要求是转诊时要有足够的临床和放射学信息。临床信息可指导辅助检测。在本综述中，我们基于TIS提供了一种实用且具教育意义的报告浆液性积液细胞学的方法。
