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Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration.

作者信息

Angelucci Francesco, Hort Jakub

机构信息

Memory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic (Angelucci F, Hort J).

International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic (Hort J).

出版信息

Neural Regen Res. 2025 Aug 1;20(8):2317-2318. doi: 10.4103/NRR.NRR-D-24-00335. Epub 2024 Sep 6.

DOI:10.4103/NRR.NRR-D-24-00335
PMID:39359087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11759028/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9865/11759028/7608867aa150/NRR-20-2317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9865/11759028/7608867aa150/NRR-20-2317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9865/11759028/7608867aa150/NRR-20-2317-g001.jpg

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本文引用的文献

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2
Aging, Plasminogen Activator Inhibitor 1, Brain Cell Senescence, and Alzheimer's Disease.衰老、纤溶酶原激活物抑制剂1、脑细胞衰老与阿尔茨海默病
Aging Dis. 2023 Apr 1;14(2):515-528. doi: 10.14336/AD.2022.1220.
3
Plasminogen decreases Aβ42 and Tau deposition, and shows multi-beneficial effects on Alzheimer's disease in mice and humans.
纤溶酶原可减少β淀粉样蛋白42（Aβ42）和 Tau蛋白沉积，并对小鼠和人类的阿尔茨海默病显示出多种有益作用。
Biochem Biophys Res Commun. 2023 Apr 30;654:102-111. doi: 10.1016/j.bbrc.2023.02.078. Epub 2023 Feb 28.
4
PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models.反应性星形胶质细胞产生 PAI-1 驱动多发性硬化模型中的组织纤维蛋白溶解异常。
Cell Mol Life Sci. 2022 May 28;79(6):323. doi: 10.1007/s00018-022-04340-z.
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Tissue Plasminogen Activator in Central Nervous System Physiology and Pathology: From Synaptic Plasticity to Alzheimer's Disease.组织型纤溶酶原激活物在中枢神经系统生理学和病理学中的作用：从突触可塑性到阿尔茨海默病。
Semin Thromb Hemost. 2022 Apr;48(3):288-300. doi: 10.1055/s-0041-1740265. Epub 2021 Dec 23.
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Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson's disease.帕金森病中纤溶酶原激活物抑制剂-1、α-突触核蛋白与神经炎症之间的协同作用。
Med Hypotheses. 2020 May;138:109602. doi: 10.1016/j.mehy.2020.109602. Epub 2020 Jan 28.
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CNS Neurosci Ther. 2019 Mar;25(3):303-313. doi: 10.1111/cns.13082. Epub 2018 Nov 6.
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Fibrinolysis: from blood to the brain.纤维蛋白溶解：从血液到大脑。
J Thromb Haemost. 2017 Nov;15(11):2089-2098. doi: 10.1111/jth.13849. Epub 2017 Oct 19.
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