Xiao Yanqing, Gao Mingming, He Zejia, Zheng Jia, Bai Hongming, Rao Jia-Sheng, Song Guiyun, Song Wei, Li Xiaoguang
Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Department of Rehabilitation Evaluation, China Rehabilitation Research Center, Beijing, China.
Neural Regen Res. 2025 Aug 1;20(8):2337-2347. doi: 10.4103/NRR.NRR-D-23-01812. Epub 2024 May 13.
JOURNAL/nrgr/04.03/01300535-202508000-00024/figure1/v/2024-09-30T120553Z/r/image-tiff Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level. However, because of prolonged inactivity, initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway. A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation, as measured by surface electromyography. In this study, we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury. Eleven patients with chronic complete thoracic spinal cord injury were recruited. Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol. The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation. Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity, the difference was not statistically significant. These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.
《期刊》/nrgr/04.03/01300535 - 202508000 - 00024/图1/v/2024 - 09 - 30T120553Z/图像 - tiff 完全性脊髓损伤患者在脊髓损伤水平以下的肌肉中仍保留自主肌肉活动的潜力。然而，由于长期不活动，最初激活这些肌肉的尝试可能无法有效地使下行通路中任何剩余的神经元参与进来。先前的一项研究意外地发现，一轮简短的临床被动活动显著增加了自主肌肉激活，这通过表面肌电图测量得出。在本研究中，我们进一步探讨了被动活动对完全性脊髓损伤个体在自主控制任务期间表面肌电信号的影响。招募了11名慢性完全性胸段脊髓损伤患者。在被动活动方案前后采集并比较了来自八条主要腿部肌肉的表面肌电图数据。结果表明，被动活动导致激活的自主肌肉数量增加以及激活频率增加。尽管在被动活动后，用于运动自主控制的表面肌电图幅度的累积均方根略有增加，但差异无统计学意义。这些发现表明，简短的被动活动可能会增强在表面肌电图任务期间启动自主肌肉活动的能力，并强调了被动活动在改善运动完全性脊髓损伤患者残余运动控制方面的潜力。
