Sinha A, Rao A R
Mutat Res. 1985 Dec;158(3):189-92. doi: 10.1016/0165-1218(85)90083-7.
The ability of arecoline, an alkaloid of betel nut, to induce abnormality in the shape of sperm heads and unscheduled DNA synthesis (UDS) in the early spermatid stages of Swiss albino mice was studied. Treatment of mice with arecoline at the dose levels of 20, 40 and 80 mg/kg elicited dose-related increase in the number of abnormal sperm heads, as well as the unscheduled incorporation of [3H]thymidine into the DNA of early spermatids. Such increase in the production of abnormally shaped sperms and UDS response of the early spermatids following arecoline treatment expressed its genotoxic potential in the mouse germ cells.
研究了槟榔碱（一种槟榔中的生物碱）在瑞士白化小鼠早期精子细胞阶段诱导精子头部形态异常和非程序性DNA合成（UDS）的能力。用20、40和80mg/kg剂量水平的槟榔碱处理小鼠，导致异常精子头部数量呈剂量相关增加，以及[3H]胸腺嘧啶核苷非程序性掺入早期精子细胞的DNA中。槟榔碱处理后早期精子细胞异形精子产生增加及UDS反应，表明其对小鼠生殖细胞具有遗传毒性潜力。
