NUP98重排在急性髓系白血病中的预后重要性：一项系统评价和荟萃分析。
Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis.
作者信息
Sheikhi Maryam, Siyadat Payam, Rostami Mehrdad, Sadeghian Mohammad Hadi, Zahiri Elnaz, Ghorbani Mohammad, Ayatollahi Hossein, Ayatollahi Amirali, Hemmatan Attarbashi Reza, Khoshnegah Zahra
机构信息
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
出版信息
Caspian J Intern Med. 2024 Aug 30;15(4):579-588. doi: 10.22088/cjim.15.4.579. eCollection 2024 Fall.
BACKGROUND
NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. Despite substantial research illuminating the roles of NUP98 fusions in the course of AML, their impacts on the outcome of patients with AML should be explored in more detail. As a result, this meta-analysis was designed to provide further light on the prognostic implications of NUP98 fusions in AML.
METHODS
We completed an extensive search in PubMed, Scopus, and Web of Science to identify papers evaluating the prognostic effects of NUP98 rearrangements in patients with AML until August 22, 2022. In total, 15 publications with 6142 participants fulfilled the requirements for the current meta-analysis. All the qualified studies were examined for information regarding HRs and 95% confidence interval (95%CI) for overall survival (OS) and event-free survival (EFS). In addition, we utilized Comprehensive Meta-analysis software version 2 (CMA2) for calculating pooled HRs and 95% CI.
SECTION TITLE
Our analyses for NUP98-NSD1 indicated that this fusion could significantly impact the outcome of patients with AML (pooled HR: 2.84; 95% CI: 2.49-3.24, =0.000). Additionally, we observed a strong correlation between NUP98-KDM5A rearrangement and poor prognosis in AML (pooled HR: 2.65; 95% CI: 2.5-2.81; P=0.000). A subgroup analysis also showed that the NUP98-NSD1 and FLT3-ITD together confer a poor prognostic effect (pooled HR: 2.60, 95% CI: 1.61-4.18; P=0.000).
CONCLUSIONS
NUP98 fusions could significantly impact the outcome of patients with AML. The use of these fusions as prognostic indicators in AML seems rational.
背景
急性髓系白血病（AML）中的NUP98基因融合最近引起了广泛关注。尽管大量研究阐明了NUP98融合在AML病程中的作用，但它们对AML患者预后的影响仍需更详细地探讨。因此，本荟萃分析旨在进一步揭示NUP98融合在AML中的预后意义。
方法
我们在PubMed、Scopus和Web of Science上进行了广泛检索，以识别评估NUP98重排在AML患者中预后影响的论文，检索截止至2022年8月22日。共有15篇包含6142名参与者的出版物符合当前荟萃分析的要求。所有合格研究均检查了总生存（OS）和无事件生存（EFS）的风险比（HR）及95%置信区间（95%CI）相关信息。此外，我们使用综合荟萃分析软件版本2（CMA2）计算合并HR和95%CI。
结果
我们对NUP98-NSD1的分析表明，这种融合可显著影响AML患者的预后（合并HR：2.84；95%CI：2.49-3.24；P=0.000）。此外，我们观察到NUP98-KDM5A重排与AML预后不良之间存在强烈相关性（合并HR：2.65；95%CI：2.5-2.81；P=0.000）。亚组分析还显示，NUP98-NSD1与FLT3-ITD共同产生不良预后影响（合并HR：2.60，95%CI：1.61-4.18；P=0.000）。
结论
NUP98融合可显著影响AML患者的预后。将这些融合作为AML的预后指标似乎是合理的。
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