Basiri Reza, Sharifnezhad Farzad, Jafarian Amir H, Samadi Sara, Zarghi Amirreza
Lung Disease Research Center, Faculty of Medicine Mashhad University of Medicine Sciences.
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences.
Ann Med Surg (Lond). 2024 Sep 10;86(10):5762-5766. doi: 10.1097/MS9.0000000000002539. eCollection 2024 Oct.
The diagnosis of peripheral pulmonary lesions (PPL) poses a significant challenge, prompting the widespread utilization of various modalities to ensure the precision in diagnosis. This study aims to assess the diagnostic accuracy of computed tomography-guided percutaneous transthoracic needle biopsy (CT-PTNB) in the context of pulmonary malignancy.
This multicenter retrospective observational study, included 1317 cases of CT-PTNB performed on adult patients with PPLs from January 2018 to December 2022 in Mashhad, Iran. The pathology results of CT-PTNB from 94 cases were compared to the definitive pathology results obtained through methods such as surgery to assess the sensitivity, specificity, and overall accuracy of CT-PTNB in diagnosing of pulmonary malignancy.
CT-PTNB exhibits an accuracy of 82.98%, with sensitivity and specificity rates of 75.41 and 91.43%, respectively. This study underscores the issue of false-negative results in CT-PTNB and underscores the importance of integrating clinical, radiological, and additional diagnostic modality to guide diagnostic decisions.
In this large-scale multicenter study, the accuracy of CT-PTNB for diagnosis of pulmonary malignancy is acceptable but fairly low compared to previous studies.
周围型肺部病变（PPL）的诊断面临重大挑战，这促使人们广泛采用各种方法以确保诊断的准确性。本研究旨在评估计算机断层扫描引导下经皮经胸针吸活检（CT-PTNB）在肺恶性肿瘤诊断中的准确性。
这项多中心回顾性观察研究纳入了2018年1月至2022年12月在伊朗马什哈德对患有PPL的成年患者进行的1317例CT-PTNB病例。将94例CT-PTNB的病理结果与通过手术等方法获得的最终病理结果进行比较，以评估CT-PTNB在诊断肺恶性肿瘤中的敏感性、特异性和总体准确性。
CT-PTNB的准确率为82.98%，敏感性和特异性分别为75.41%和91.43%。本研究强调了CT-PTNB中假阴性结果的问题，并强调了整合临床、放射学和其他诊断方法以指导诊断决策的重要性。
在这项大规模多中心研究中，CT-PTNB诊断肺恶性肿瘤的准确性是可以接受的，但与以往研究相比相当低。
