Liester Mitchell B, Shash Delia S
Psychiatry, University of Colorado School of Medicine, Colorado Springs, USA.
Obstetrics and Gynecology, University of Arizona, Phoenix, USA.
Cureus. 2024 Sep 2;16(9):e68447. doi: 10.7759/cureus.68447. eCollection 2024 Sep.
Conventional antidepressants are useful in the treatment of major depressive disorder (MDD) but are limited by their delayed onset of action and lack of adequate therapeutic response in approximately one-third of patients. This has led to a quest for faster-acting and more effective antidepressants. Scopolamine exhibits rapid antidepressant effects when administered intravenously. We report a case of a female with treatment-resistant depression (TRD) who responded to transdermal scopolamine. She had a rapid (within three days) and sustained (119 days) response to transdermal scopolamine. Further research into the use of transdermal scopolamine for the treatment of depression is recommended.
传统抗抑郁药对治疗重度抑郁症（MDD）有效，但受起效延迟限制，且约三分之一的患者缺乏足够的治疗反应。这促使人们寻求起效更快、更有效的抗抑郁药。静脉注射东莨菪碱时具有快速抗抑郁作用。我们报告一例难治性抑郁症（TRD）女性患者，其对透皮东莨菪碱有反应。她对透皮东莨菪碱有快速（三天内）且持续（119天）的反应。建议进一步研究透皮东莨菪碱在抑郁症治疗中的应用。
