无急性葡萄膜炎的幼年特发性关节炎患者的脉络膜血管分析
Choroidal vascularity analysis in patients with juvenile idiopathic arthritis without acute uveitis.
作者信息
Iaccheri Barbara, De Santi Nicola, Cerquaglia Alessio, Della Lena Francesco, Bianchi Eduardo, Fruttini Daniela, Gerli Veronica, Chhablani Jay, Cagini Carlo, Fiore Tito
机构信息
Section of Ophthalmology, Department of Medicine and Surgery, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy.
Section of Internal Medicine, Department of Medicine and Surgery, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy.
出版信息
Clin Exp Rheumatol. 2025 Jan;43(1):145-150. doi: 10.55563/clinexprheumatol/nddba1. Epub 2024 Oct 3.
OBJECTIVES
We aimed to investigate choroidal involvement and the degree of anterior chamber inflammation in a cohort of patients with juvenile idiopathic arthritis (JIA) without clinical signs of active uveitis and to compare it with healthy controls (HC).
METHODS
Enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of 21 patients diagnosed with JIA and 22 HC of equal age were acquired. Images were binarised to measure subfoveal choroidal thickness (SCT), nasal choroidal thickness (NCT), temporal choroidal thickness (TCT), total choroidal area (TCA), luminal area (LA), stromal area (SA) and choroidal vascular index (CVI). Patients also underwent a measurement of the degree of inflammation in the anterior chamber by laser flare meter (LFM).
RESULTS
No significant differences were found in the choroidal thickness in the subfoveal region (p=0.274), nasally to the fovea (p=0.568) and temporally to the fovea (p=0.430) between JIA patients and HC. No statistically significant difference in the choroidal area (TCA, LA and SA) between the JIA patients and HC were found. Moreover, CVI was not significantly different between the two groups (p=0.166), while the LFM of the JIA patients and HC (p=0.002) revealed a statistically significant difference.
CONCLUSIONS
In the absence of active uveitis, choroidal thickness and vascularity are not significantly different in JIA patients and HC.
目的
我们旨在调查一组无活动性葡萄膜炎临床体征的青少年特发性关节炎（JIA）患者的脉络膜受累情况及前房炎症程度，并将其与健康对照者（HC）进行比较。
方法
对21例诊断为JIA的患者和22例年龄匹配的HC进行增强深度成像光学相干断层扫描（EDI-OCT）。将图像二值化以测量黄斑中心凹下脉络膜厚度（SCT）、鼻侧脉络膜厚度（NCT）、颞侧脉络膜厚度（TCT）、脉络膜总面积（TCA）、管腔面积（LA）、基质面积（SA）和脉络膜血管指数（CVI）。患者还通过激光散射仪（LFM）测量前房炎症程度。
结果
JIA患者与HC在黄斑中心凹下区域（p=0.274）、黄斑鼻侧（p=0.568）和黄斑颞侧（p=0.430）的脉络膜厚度无显著差异。JIA患者与HC在脉络膜面积（TCA、LA和SA）上无统计学显著差异。此外，两组间CVI无显著差异（p=0.166），而JIA患者与HC的LFM结果（p=0.002）显示有统计学显著差异。
结论
在无活动性葡萄膜炎的情况下，JIA患者与HC的脉络膜厚度和血管情况无显著差异。
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