Guo Nan, Gui Yu-Jia, Chen Ying
Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Semin Ophthalmol. 2025 Apr;40(3):169-172. doi: 10.1080/08820538.2024.2412050. Epub 2024 Oct 3.
To present a treatment regimen for Brucellosis endophthalmitis that resulted in a good visual outcome. Additionally, we conducted a literature review on the treatment and visual prognosis of related cases.
A 49-year-old woman with the chief complaint of decreased vision and redness in the right eye was initially diagnosed with noninfectious uveitis and prescribed high-dose steroids which led to transient improvement followed by a decline in vision. An infectious cause was suspected. Metagenomic next-generation sequencing of vitreous fluid and serological testing confirmed Brucella melitensis infection. The patient underwent vitrectomy combined with six intravitreal injections of ceftazidime in the right eye in addition to systemic antibiotic treatment. The intraocular inflammation was completely resolved, and the visual acuity recovered to 20/25, which is the best-documented recovery in Brucella endophthalmitis cases, as revealed by the literature review.
Vitrectomy combined with repeated intravitreal injections of ceftazidime can enhance the treatment for brucellosis endophthalmitis and achieve a better visual prognosis.
介绍一种治疗布鲁氏菌性眼内炎并取得良好视力预后的治疗方案。此外，我们对相关病例的治疗及视力预后进行了文献综述。
一名49岁女性，以右眼视力下降和眼红为主诉，最初被诊断为非感染性葡萄膜炎，并给予高剂量类固醇治疗，视力短暂改善后又下降。怀疑有感染原因。玻璃体液的宏基因组下一代测序和血清学检测证实为羊布鲁氏菌感染。除全身抗生素治疗外，患者右眼接受了玻璃体切除术，并联合6次玻璃体内注射头孢他啶。眼内炎症完全消退，视力恢复到20/25，如文献综述所示，这是布鲁氏菌性眼内炎病例中记录最好的恢复情况。
玻璃体切除术联合反复玻璃体内注射头孢他啶可增强对布鲁氏菌性眼内炎的治疗效果，并取得更好的视力预后。
