Department of Magnetic Resonance Imaging, Cangzhou Central Hospital, China.
Department of Radiology, The Eighth Medical Center of Chinese PLA General Hospital, China.
Curr Med Imaging. 2024;20:e15734056318603. doi: 10.2174/0115734056318603240910115315.
This study aimed to verify whether the Liver-to-portal Ratio (LPR) can assess the adequacy of the Hepatobiliary Phase (HBP) for patients with different liver functions.
A total of 125 patients were prospectively enrolled in the study and graded into the non-cirrhosis group (45), Child-Pugh A group (40), and Child- Pugh B/C group (40). The LPR on HBP was calculated after eight HBPs were obtained within 5-40 minutes. The adequate HBP was determined according to the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus statement. The differences in LPR and lesions' conspicuity between 10-min HBP and adequate HBP were analyzed by paired t-test and Wilcoxon signed-rank test, respectively. The chisquare test was used to test the difference in proportion with LPR larger than 1.462 between 10-min HBP and adequate HBP.
The differences in LPR and lesions' conspicuity between 10-min HBP and adequate HBP were significant in Child-Pugh A and Child-Pugh B/C groups (P < 0.05), except for the non-cirrhosis group (P > 0.05). The differences in proportion with LPR larger than 1.462 between 10-min HBP and adequate HBP were not statistically significant in all groups (all P > 0.05).
The adequate HBP obtained according to the 2016 ESGAR consensus statement could provide larger LPR and better lesions' conspicuity than 10- min HBP, especially for cirrhotic patients; however, the efficacy of using an LPR cutoff of 1.462 as the standard of the adequate HBP may be compromised in patients with cirrhosis.
本研究旨在验证肝门静脉比值（LPR）能否评估不同肝功能患者的肝胆期（HBP）是否充分。
本研究前瞻性纳入了 125 名患者，并将其分为非肝硬化组（45 例）、Child-Pugh A 级组（40 例）和 Child-Pugh B/C 级组（40 例）。在 5-40 分钟内获得 8 次 HBP 后，计算 HBP 时的 LPR。根据 2016 年欧洲胃肠道和腹部放射学会（ESGAR）共识声明，确定充分的 HBP。采用配对 t 检验和 Wilcoxon 符号秩检验分别分析 10 分钟 HBP 和充分 HBP 时 LPR 和病变显影之间的差异。采用卡方检验比较 10 分钟 HBP 和充分 HBP 时 LPR 大于 1.462 的比例差异。
在 Child-Pugh A 级和 Child-Pugh B/C 级组中，10 分钟 HBP 和充分 HBP 时 LPR 和病变显影的差异有统计学意义（P < 0.05），而非肝硬化组无统计学意义（P > 0.05）。各组中 10 分钟 HBP 和充分 HBP 时 LPR 大于 1.462 的比例差异均无统计学意义（均 P > 0.05）。
根据 2016 年 ESGAR 共识声明获得的充分 HBP 可以提供比 10 分钟 HBP 更大的 LPR 和更好的病变显影，特别是对于肝硬化患者；然而，使用 LPR 截断值 1.462 作为充分 HBP 标准的效果在肝硬化患者中可能会受到影响。
