血清Metrnl水平低与老年人肌肉减少症风险增加有关。
Low serum Metrnl levels are associated with increased risk of sarcopenia in the older adults.
作者信息
Wang Zhi-Yue, Li Yi-Min, Yan Jian-Jun, Wang Quan, Zhao Can, Lu Xiang, Shen Zheng-Kai, Xu Jin-Shui, Gao Wei
机构信息
Department of Geriatrics, Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, Yancheng, China.
Department of Cardiology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
出版信息
Eur Geriatr Med. 2024 Dec;15(6):1849-1857. doi: 10.1007/s41999-024-01074-y. Epub 2024 Oct 3.
PURPOSE
Sarcopenia is a geriatric syndrome characterized by progressive loss of muscle mass and function. Meteorin-like (Metrnl) is a secretory protein that has protective effects on skeletal muscle injury. However, the association of Metrnl level with sarcopenia remains unclear.
METHODS
A total of 772 community-dwelling older adults (median age = 76 years), comprising 409 males and 363 females, from both urban and rural areas were enrolled. Serum Metrnl was measured by enzyme-linked immunosorbent assay. Appendicular skeletal muscle mass index (ASMI), grip strength, and gait speed were measured for the assessment of sarcopenia.
RESULTS
We found that serum Metrnl levels were lower in patients with sarcopenia [median (IQR) = 180.1 (151.3-220.3) pg/mL] than older adults without sarcopenia [211.9 (163.2-270.0) pg/mL, P < 0.001]. Receiver-operating characteristic curve analysis showed that the optimal cut-off value of serum Metrnl level that predicted sarcopenia was 197.2 pg/mL with a sensitivity of 59.2% and a specificity of 63.8% (AUC = 0.63, 95% CI = 0.59-0.67, P < 0.001). Multivariate logistic regression analyses showed that lower serum Metrnl level (< 197.2 pg/mL) was significantly associated with increased risk of sarcopenia (adjusted OR = 2.358, 2.36, 95% CI = 1.528-3.685, P < 0.001). Moreover, serum Metrnl concentration was positively correlated with the components of sarcopenia including ASMI (r = 0.135, P < 0.001), grip strength (r = 0.102, P = 0.005), and gait speed (r = 0.106, P = 0.003).
CONCLUSIONS
Taken together, our findings demonstrate that low serum Metrnl level is correlated with increased risk of sarcopenia in the older adults.
目的
肌肉减少症是一种以肌肉质量和功能逐渐丧失为特征的老年综合征。类陨石蛋白（Metrnl）是一种对骨骼肌损伤具有保护作用的分泌蛋白。然而，Metrnl水平与肌肉减少症之间的关联仍不清楚。
方法
共纳入772名来自城市和农村地区的社区居住老年人（中位年龄 = 76岁），其中男性409名，女性363名。采用酶联免疫吸附测定法检测血清Metrnl水平。测量四肢骨骼肌质量指数（ASMI）、握力和步速以评估肌肉减少症。
结果
我们发现，肌肉减少症患者的血清Metrnl水平[中位数（IQR）= 180.1（151.3 - 220.3）pg/mL]低于无肌肉减少症的老年人[211.9（163.2 - 270.0）pg/mL，P < 0.001]。受试者工作特征曲线分析表明，预测肌肉减少症的血清Metrnl水平的最佳截断值为197.2 pg/mL，敏感性为59.2%，特异性为63.8%（AUC = 0.63，95% CI = 0.59 - 0.67，P < 0.001）。多因素逻辑回归分析表明，较低的血清Metrnl水平（< 197.2 pg/mL）与肌肉减少症风险增加显著相关（调整后的OR = 2.358，2.36，95% CI = 1.528 - 3.685，P < 0.001）。此外，血清Metrnl浓度与肌肉减少症的各项指标呈正相关，包括ASMI（r = 0.135，P < 0.001）、握力（r = 0.102，P = 0.005）和步速（r = 0.106，P = 0.003）。
结论
综上所述，我们的研究结果表明，老年人血清Metrnl水平低与肌肉减少症风险增加相关。
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