Instituto Mexicano del Seguro Social, Coordinación de Calidad de Insumos y Laboratorios Especializados, México, México.
Instituto Mexicano del Seguro Social, Coordinación de Vigilancia Epidemiológica, México, México.
PLoS One. 2024 Oct 3;19(10):e0307322. doi: 10.1371/journal.pone.0307322. eCollection 2024.
Respiratory viruses have clinical and epidemiological importance. With the COVID-19 pandemic, interest has focused on SARS-CoV-2, but as a result, the number of samples available for the differential diagnosis of other respiratory viruses has increased.
Cross-sectional study.
To describe the epidemiological behavior of respiratory viruses based on a laboratory-based epidemiological surveillance system using data from 2017 to 2023.
Univariate, bivariate and multivariate analyses of data from a laboratory database of respiratory viruses detected by multiplex RT‒qPCR were performed.
A total of 4,632 samples with positive results for at least 1 respiratory virus, not including influenza or SARS-CoV-2, were analyzed. The most common virus detected was respiratory syncytial virus in 1,467 (26.3%) samples, followed by rhinovirus in 1,384 (24.8%) samples. Most of the samples were from children under 5 years of age. The age-adjusted odds ratio (OR) of death for patients infected with parainfluenza virus 4 was 4.1 (95% confidence interval [95% CI] 2.0-8.2).
Respiratory syncytial virus and rhinovirus had the highest frequency and proportion of coinfections, whereas parainfluenza virus 4 was associated with an increased risk of death.
呼吸道病毒具有临床和流行病学意义。随着 COVID-19 大流行，人们对 SARS-CoV-2 的关注度有所提高，但结果是，可用于其他呼吸道病毒鉴别诊断的样本数量增加了。
横断面研究。
基于使用 2017 年至 2023 年数据的基于实验室的流行病学监测系统，描述呼吸道病毒的流行病学行为。
对多重 RT-qPCR 检测到的呼吸道病毒实验室数据库中的数据进行单变量、双变量和多变量分析。
共分析了 4632 份至少检测到 1 种呼吸道病毒（不包括流感或 SARS-CoV-2）的阳性样本。最常见的病毒是呼吸道合胞病毒，在 1467 份样本（26.3%）中检测到，其次是鼻病毒，在 1384 份样本（24.8%）中检测到。大多数样本来自 5 岁以下儿童。感染副流感病毒 4 的患者死亡的年龄调整比值比（OR）为 4.1（95%置信区间 [95%CI] 2.0-8.2）。
呼吸道合胞病毒和鼻病毒的频率和合并感染比例最高，而副流感病毒 4 与死亡风险增加相关。
