J Drugs Dermatol. 2024 Oct 1;23(10):54122s4-54122s11.
Acne vulgaris is an extremely common dermatologic condition. Individuals with acne present not only to dermatologists, but also to internists, family medicine physicians, pediatricians, estheticians, and beauty counters alike in search of a treatment. The diagnosis of acne is relatively straightforward, leading many to believe that acne is a simple condition. However, the pathophysiology of acne is anything but simple. Decades of research has ultimately revealed a complex interaction of pathogenic factors that lead to acne. This includes sebum production, C. acnes colonization, inflammation, and follicular hyperkeratinization. Understanding each of these features has been fundamental to the development of anti-acne medications. Topical agents are often used as an initial therapy given their safety and efficacy. While some topical therapies have been used for decades, new creams, gels, and lotions continue to be added to the list of approved acne treatments. Given the number of topical acne products on the market, we present an updated review of the current landscape of topical acne treatments and how each choice functions mechanistically to fight against acne. J Drugs Dermatol. 2024;23:10(Suppl 1):s4-11.
寻常痤疮是一种极为常见的皮肤科疾病。患有痤疮的患者不仅会到皮肤科就诊，还会到内科医生、家庭医生、儿科医生、美容师和美容专柜寻求治疗。痤疮的诊断相对简单，这导致许多人认为痤疮是一种简单的疾病。然而，痤疮的病理生理学绝非如此简单。数十年的研究最终揭示了导致痤疮的一系列复杂致病因素的相互作用。这包括皮脂产生、痤疮丙酸杆菌定植、炎症和毛囊过度角化。了解这些特征对于开发抗痤疮药物至关重要。局部药物通常作为初始治疗药物使用，因为它们具有安全性和疗效。虽然一些局部治疗方法已经使用了几十年，但新的乳膏、凝胶和洗剂不断被添加到批准的痤疮治疗药物清单中。鉴于市场上有大量的局部痤疮产品，我们对当前局部痤疮治疗方法的现状进行了更新综述，并介绍了每种方法如何通过机制对抗痤疮。J 皮肤病药物杂志。2024;23:10(增刊 1):s4-11。
