College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Department of Food Science, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Adv Sci (Weinh). 2024 Nov;11(44):e2401172. doi: 10.1002/advs.202401172. Epub 2024 Oct 3.
Bioactive food ingredients contribute to the promotion and maintenance of human health and wellbeing. However, these functional ingredients often exhibit low biopotency after food processing or gastrointestinal transit. Well-designed oral delivery systems can increase the ability of bioactive food ingredients to resist harsh environments inside and outside the human body, as well as allow for controlled or triggered release of bioactives to specific sites in the gastrointestinal tract or other tissues and organs. This review presents the characteristics of common bioactive food ingredients and then highlights the barriers to their biopotency. It also discusses various oral delivery strategies and carrier types that can be used to overcome these biopotency barriers, with a focus on recent advances in the field. Additionally, the advantages and disadvantages of different delivery strategies are highlighted. Finally, the current challenges facing the development of food-grade oral delivery systems are addressed, and areas where future research can lead to new advances and industrial applications of these systems are proposed.
生物活性食品成分有助于促进和维持人类健康和福祉。然而，这些功能性成分在经过食品加工或胃肠道转运后往往表现出低生物活性。精心设计的口服给药系统可以提高生物活性食品成分抵抗人体内外恶劣环境的能力，并允许对胃肠道或其他组织和器官的特定部位进行生物活性的控制或触发释放。本综述介绍了常见生物活性食品成分的特性，然后重点介绍了其生物活性的障碍。它还讨论了可以用来克服这些生物活性障碍的各种口服给药策略和载体类型，重点介绍了该领域的最新进展。此外，还强调了不同给药策略的优缺点。最后，讨论了开发食品级口服给药系统所面临的挑战，并提出了未来研究可以在哪些方面为这些系统的新进展和工业应用提供指导。
