Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, China.
The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113285. doi: 10.1016/j.intimp.2024.113285. Epub 2024 Oct 2.
Interleukin-33 (IL-33) is a pleiotropic cytokine of the IL-1 family that plays a key role in innate and adaptive immune responses and contributes to tissue homeostasis. Its role in adipose tissue function has been extensively studied, as adipose tissue serves as an important mediator of metabolic dysfunction. In adipose tissue, IL-33 is primarily produced by stromal cells. Its production is regulated by factors, such as androgens, aging, sympathetic innervation, and various inflammatory stimuli that affect the proliferation and differentiation of IL-33-producing stromal cells. Many studies have elucidated the mechanisms by which IL-33 interacts with the immune system components, local nerve fibers, and adipocytes to influence energy balance, with important consequences in obesity, cold-induced thermogenesis, and aging-related metabolic dysfunction. Here, we detail our current understanding of the molecular events that regulate the production of IL-33 within adipose tissue and discuss its role in regulating adipose function.
白细胞介素 33（IL-33）是白细胞介素 1 家族的一种多效细胞因子，在先天和适应性免疫反应中发挥关键作用，并有助于组织稳态。它在脂肪组织功能中的作用已得到广泛研究，因为脂肪组织是代谢功能障碍的重要介质。在脂肪组织中，IL-33 主要由基质细胞产生。其产生受多种因素调节，如雄激素、衰老、交感神经支配和各种炎症刺激，这些因素影响产生 IL-33 的基质细胞的增殖和分化。许多研究阐明了 IL-33 与免疫系统成分、局部神经纤维和脂肪细胞相互作用的机制，以影响能量平衡，这对肥胖、冷诱导产热和与年龄相关的代谢功能障碍有重要影响。在这里，我们详细介绍了我们目前对调节脂肪组织中 IL-33 产生的分子事件的理解，并讨论了它在调节脂肪功能中的作用。
