Utiamyshev R I, Aref'ev I M, Mazovetskiĭ A G, Shevchenko R A
Ter Arkh. 1985;57(9):120-6.
The paper is concerned with the results of studies on the basal blood flow and responses of the microcirculatory channel to physiological and pharmacological loads in health and diabetes mellitus using the method of photon-correlation spectroscopy in the light fiber variant. The rate of the basal blood flow in patients with diabetes mellitus (irrespective of the diabetes type) as compared to that in health was significantly lower in the finger tip and tended toward reduction in the inner side of the forearm, lobule of the auricle and in the conjunctiva. The presence of retinopathies in patients with diabetes mellitus resulted in a significant decrease in the rate of the blood flow in the conjunctiva as compared to those in health and diabetes mellitus without retinopathy. The response of the blood flow to physiological (orthostatic and ischemic) and pharmacological (nitroglycerin and pentoxifyllin) tests in patients with diabetes mellitus was also low; the presence of angiopathies caused a more acute reduction of the reactive power of the microcirculatory channel to the orthostatic test. The nature of the nitroglycerin effect in health and diabetes mellitus was different: in the first case noticeable vascular reactions were observed, in the second case a persistent vasodilative effect was observed. The pentoxifyllin effect was characterized by an elevated rate of the blood flow in health and diabetes mellitus.
本文关注的是采用光纤变体中的光子相关光谱法，对健康人和糖尿病患者的基础血流以及微循环通道对生理和药理负荷的反应所进行的研究结果。与健康人相比，糖尿病患者（无论糖尿病类型如何）指尖的基础血流速率显著降低，前臂内侧、耳廓小叶和结膜处的基础血流速率有降低趋势。与无视网膜病变的健康人和糖尿病患者相比，糖尿病视网膜病变患者结膜处的血流速率显著降低。糖尿病患者血流对生理（直立位和缺血）和药理（硝酸甘油和己酮可可碱）试验的反应也较低；血管病变的存在导致微循环通道对直立位试验的反应性降低更为明显。硝酸甘油在健康人和糖尿病患者中的作用性质不同：在前者中观察到明显的血管反应，在后者中观察到持续的血管舒张作用。己酮可可碱的作用特点是在健康人和糖尿病患者中血流速率升高。
