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A型血友病:在中东和北非地区的经济负担、治疗进展和未来预测。

Hemophilia A: Economic burden, therapeutic advances, and future forecasts in the Middle East and North Africa region.

机构信息

Medical Affairs Department, Volaris LLC, Dubai, United Arab Emirates; Clinical Pharmacy & HEOR, Cairo University Hospitals, Cairo, Egypt.

Medical Affairs Department, Volaris LLC, Dubai, United Arab Emirates.

出版信息

Thromb Res. 2024 Nov;243:109175. doi: 10.1016/j.thromres.2024.109175. Epub 2024 Sep 28.

Abstract

Hemophilia A, a severe hereditary hemorrhagic disorder characterized by a deficiency in blood clotting factors, imposes a significant economic burden on individuals, healthcare systems, and society, with inhibitors exacerbating the socioeconomic impact. The detrimental impact on the quality of life for patients and caregivers, including functional limitations, is particularly pronounced during bleeding episodes and in the presence of inhibitors. The increasing prevalence of Hemophilia A across the MENA region is evident, marked by the approval of various therapies and intensified research and development efforts focusing on treatment innovations. Despite commendable progress in Hemophilia management, challenges persist in providing care for Hemophilia patients in the region. This review aims to shed light on the current landscape, challenges, and market forecasts for Hemophilia A in the MENA region. Additionally, it strives to provide valuable insights for the future, emphasizing the need for clear approaches to ensure comprehensive care for individuals with Hemophilia.

摘要

甲型血友病是一种严重的遗传性出血性疾病,其特征是血液凝血因子缺乏,给个人、医疗保健系统和社会带来了巨大的经济负担,而抑制剂则加剧了这种社会经济影响。在出血发作期间和存在抑制剂的情况下,患者及其照顾者的生活质量受到严重影响,包括功能受限。中东和北非地区甲型血友病的发病率不断上升,这表明各种疗法的批准以及针对治疗创新的研究和开发工作的加强。尽管在血友病管理方面取得了可喜的进展,但该地区为血友病患者提供护理方面仍然存在挑战。本综述旨在探讨中东和北非地区甲型血友病的现状、挑战和市场预测,并为未来提供有价值的见解,强调需要采取明确的方法来确保为血友病患者提供全面的护理。

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