Barnhart Heather, Aviles Frank, Pannunzio Johanna, Sirkis Nathan, Hubbard Chantel, Hardigan Patrick, Ginsburg Sabrina, Mayrovitz Harvey, Eckert Kristen A, Melin M Mark
Department of Physical Therapy, Dr. Pallavi Patel College of Health Care Science, Nova Southeastern University, Fort Lauderdale, FL, USA.
Hyperbaric Physicians of Georgia, Cumming, GA, USA.
NPJ Microgravity. 2024 Oct 3;10(1):93. doi: 10.1038/s41526-024-00429-w.
This retrospective case series (clinicaltrials.gov NCT06405282) used noninvasive imaging devices (NIID) to assess the effect of manual lymphatic drainage (MLD) on dermal/venous fluid distribution, perfusion, and temperature alterations of the head, neck, upper torso, and legs while in the 6-degree head-down tilt validated spaceflight analog. A lymphatic fluid scanner measured tissue dielectric constant levels. Near-infrared spectroscopy assessed perfusion, by measuring tissue oxygenation saturation. Long-wave infrared thermography measured tissue temperature gradients. Fifteen healthy, university students participated. NIID assessments were taken 1 minute after assuming the HDT position and then every 30 minutes, with MLD administered from 180 to 195 minutes. Subjects returned to the sitting position and were assessed at post-225 min NIID demonstrated significant changes from baseline (p < 0.01), although these changes at areas of interest varied. MLD had a reverse effect on all variables. NIID assessment supported the potential use of MLD to mitigate fluid shifts during a spaceflight analog.
这个回顾性病例系列研究（clinicaltrials.gov NCT06405282）使用非侵入性成像设备（NIID），在经过验证的6度头低位倾斜模拟太空飞行状态下，评估手动淋巴引流（MLD）对头部、颈部、上半身和腿部的皮肤/静脉液体分布、灌注及温度变化的影响。一台淋巴液扫描仪测量组织介电常数水平。近红外光谱法通过测量组织氧合饱和度来评估灌注情况。长波红外热成像测量组织温度梯度。15名健康大学生参与了研究。在受试者处于头低位倾斜位置1分钟后进行NIID评估，之后每30分钟评估一次，在180至195分钟期间进行MLD。受试者恢复坐姿，并在225分钟后进行评估。NIID显示与基线相比有显著变化（p < 0.01），尽管感兴趣区域的这些变化各不相同。MLD对所有变量都有相反的影响。NIID评估支持MLD在模拟太空飞行期间减轻液体转移的潜在用途。
