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根提取物对骨质疏松症大鼠的护骨作用：系统评价和荟萃分析。

Osteoprotective effect of root extract on osteoporotic rats: a systematic review and meta-analysis.

机构信息

The Clinical Medical College, Chengdu University of Chinese Medicine, Chengdu City, Sichuan Province, China.

The Health Preservation and Rehabilitation College, Chengdu University of Chinese Traditional Medicine, Chengdu City, Sichuan Province, China.

出版信息

Pharm Biol. 2024 Dec;62(1):691-701. doi: 10.1080/13880209.2024.2407531. Epub 2024 Oct 3.

DOI:10.1080/13880209.2024.2407531
PMID:39363520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11457373/
Abstract

CONTEXT

Blume (ABB), a plant of Amaranthaceae family, has been one of the more commonly used phytomedicine remedies for thousands of years, and recent studies have highlighted the efficacy of its extracts in the treatment of osteoporosis. Nonetheless, a thorough analysis of its benefits is currently absent.

OBJECTIVE

This meta-analysis assessed the effects of ABB root extract (ABBRE) on osteoporotic rats and provides a rationale for future clinical studies.

METHODS

Searches were conducted in seven different Chinese and English databases, and the search period was from their establishment to January 2024. This study was registered in PROSPERO (CRD42023418917). Selected research regarding the ABBRE treatment of osteoporotic rats, and the corresponding research has distinctly reported outcomes, and the data on the bone mineral density (BMD), bone histomorphometrics, biomechanical parameters, and bone biochemical markers of osteoporotic rats can be extracted.

RESULTS

Through screening, 11 studies met the eligibility requirements for inclusion, in which 222 animals were studied. The treatment group with ABBRE exhibited increased bone mineral density (standardized mean difference [SMD] = 1.64, 95% CI = 0.52 to 2.77). Based on subgroup analysis, the greatest increase in bone mineral density was observed when the dose of ABBRE was ≤ 400 mg/kg/day and the duration of treatment was ≤ 12 weeks.

CONCLUSIONS

ABBRE is a phytomedicine that can effectively promote the enhancement of bone mineral density and ease osteoporosis. It can be developed into a new alternative therapy by conducting experiments and clinical studies on larger samples.

摘要

背景

猪毛菜（ABB）是苋科植物家族中的一员，几千年来一直是一种常用的植物药疗法，最近的研究强调了其提取物在治疗骨质疏松症方面的功效。尽管如此，目前仍缺乏对其益处的全面分析。

目的

本荟萃分析评估了 ABB 根提取物（ABBRE）对骨质疏松症大鼠的影响，并为未来的临床研究提供了依据。

方法

在七个不同的中文和英文数据库中进行了检索，检索时间从数据库建立到 2024 年 1 月。本研究已在 PROSPERO（CRD42023418917）中注册。选择了关于 ABBRE 治疗骨质疏松症大鼠的研究，并明确报告了相应的研究结果，且可以提取骨质疏松症大鼠的骨密度（BMD）、骨组织形态计量学、生物力学参数和骨生化标志物的数据。

结果

通过筛选，符合纳入标准的研究有 11 项，其中涉及 222 只动物。ABRE 治疗组的骨密度增加（标准化均数差[SMD] = 1.64，95%置信区间[CI] = 0.52 至 2.77）。根据亚组分析，当 ABBRE 剂量≤400 mg/kg/天且治疗时间≤12 周时，骨密度增加最大。

结论

ABRE 是一种植物药，能有效促进骨密度的提高，缓解骨质疏松症。通过对更大样本进行实验和临床研究，可以将其开发成一种新的替代疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f5/11457373/80349de8740e/IPHB_A_2407531_F0010_B.jpg
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9
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