应用于马来西亚肌萎缩侧索硬化症登记处的多步骤建模
Multistep modeling applied to a Malaysian ALS registry.
作者信息
Capelle David Paul, Sabirin Wafa, Zulhairy-Liong Nurul Angelyn, Edgar Suzanna, Goh Khean-Jin, Ahmad-Annuar Azlina, Shahrizaila Nortina
机构信息
Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia and.
Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
出版信息
Amyotroph Lateral Scler Frontotemporal Degener. 2025 Feb;26(1-2):157-161. doi: 10.1080/21678421.2024.2410280. Epub 2024 Oct 3.
OBJECTIVE
To apply the multistep model of pathogenesis in amyotrophic lateral sclerosis (ALS) to data from a multiethnic Malaysian registry.
METHODS
Clinical data, including age at symptom onset, was collected from 289 patients who presented to our multidisciplinary clinic from 2016 until 2024. A least squares linear regression model was constructed from the logarithm of approximated incidence and the logarithm of age. Population incidence was approximated by adjusting the absolute numbers of patients in 5 year groups by the size of the general population in the respective age group.
RESULTS
A linear relationship between log of incidence versus log of age was observed, with a slope of 4.57 (95% CI, 3.3-5.8) and an value of 0.93, suggesting a 6-step process.
CONCLUSION
Progression toward symptom onset in Malaysian ALS patients appears consistent with a multistep model of disease as observed in other cohorts.
目的
将肌萎缩侧索硬化症（ALS）发病机制的多步骤模型应用于马来西亚多民族登记处的数据。
方法
收集了2016年至2024年到我们多学科诊所就诊的289例患者的临床数据，包括症状出现时的年龄。根据近似发病率的对数和年龄的对数构建了最小二乘线性回归模型。通过用各年龄组总人口规模调整5年组患者的绝对数量来近似总体发病率。
结果
观察到发病率对数与年龄对数之间呈线性关系，斜率为4.57（95%可信区间，3.3 - 5.8），r值为0.93，表明为6步过程。
结论
马来西亚ALS患者出现症状的进展似乎与其他队列中观察到的疾病多步骤模型一致。
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