铁腕出击：武装自然杀伤细胞以对抗卵巢癌。
Ironing Out the Kinks: Arming Natural Killer Cells against Ovarian Cancer.
机构信息
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan.
Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, Michigan.
出版信息
Cancer Discov. 2024 Oct 4;14(10):1771-1773. doi: 10.1158/2159-8290.CD-24-1012.
Ameliorating the tumor immune microenvironment is a key strategy to improve the therapeutic outcomes of patients with cancer. Sandoval and colleagues demonstrate that iron chelation enhances type I IFN production, promotes NK cell tumor trafficking and activation, and synergizes with chemotherapy drug cisplatin to reduce metastatic ovarian cancer progression in murine models. See related article by Sandoval et al., p. 1901.
改善肿瘤免疫微环境是提高癌症患者治疗效果的关键策略。桑多瓦尔及其同事证明，螯合铁可以增强 I 型干扰素的产生，促进 NK 细胞向肿瘤迁移和激活，并与化疗药物顺铂协同作用，减少小鼠模型中转移性卵巢癌的进展。见桑多瓦尔等人的相关文章，第 1901 页。
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