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Single-cell analysis of the T-cell receptor repertoire in untreated myeloma patients suggests potential myelomareactive CD8 T cells are shared between blood and marrow.

作者信息

Favaloro James, Bryant Christian E, Abadir Edward, Gardiner Samuel, Yang Shihong, King Tracy, Nassif Najah, O'Brien Bronwyn A, Sedger Lisa M, Boyle Richard, Joshua Douglas E, Ho P Joy

机构信息

Institute of Hematology, Multiple Myeloma Research Laboratory, New South Wales Health Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; School of Life Sciences, University of Technology Sydney, Ultimo, New South Wales.

Institute of Hematology, Multiple Myeloma Research Laboratory, New South Wales Health Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; Sydney Medical School, the University of Sydney, Sydney, New South Wales.

出版信息

Haematologica. 2025 Feb 1;110(2):507-513. doi: 10.3324/haematol.2024.285952.

DOI:10.3324/haematol.2024.285952
PMID:39363853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11788622/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f7/11788622/e1901568006f/110507.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f7/11788622/e09c44b16cd0/110507.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f7/11788622/e1901568006f/110507.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f7/11788622/e09c44b16cd0/110507.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f7/11788622/e1901568006f/110507.fig2.jpg

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本文引用的文献

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Single-cell analysis of the CD8 T-cell compartment in multiple myeloma reveals disease specific changes are chiefly restricted to a CD69 subset suggesting potent cytotoxic effectors exist within the tumor bed.对多发性骨髓瘤 CD8 T 细胞区室进行单细胞分析表明，疾病特异性变化主要局限于 CD69 亚群，这表明在肿瘤床内存在有效的细胞毒性效应器。
Haematologica. 2024 Apr 1;109(4):1220-1232. doi: 10.3324/haematol.2023.283062.
2
Inverse relationship between oligoclonal expanded CD69- TTE and CD69+ TTE cells in bone marrow of multiple myeloma patients.多发性骨髓瘤患者骨髓中寡克隆扩增的CD69 - TTE细胞与CD69 + TTE细胞之间的负相关关系。
Blood Adv. 2020 Oct 13;4(19):4593-4604. doi: 10.1182/bloodadvances.2020002237.
3
Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs.
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Front Immunol. 2020 Aug 25;11:1803. doi: 10.3389/fimmu.2020.01803. eCollection 2020.
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Multiple myeloma: 2020 update on diagnosis, risk-stratification and management.多发性骨髓瘤：2020 年诊断、风险分层和治疗更新。
Am J Hematol. 2020 May;95(5):548-567. doi: 10.1002/ajh.25791.
5
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.全基因组 CRISPR 筛选鉴定流感 A 病毒感染的宿主依赖性因素。
Nat Commun. 2020 Jan 9;11(1):164. doi: 10.1038/s41467-019-13965-x.
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Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires.检测全 T 细胞受体序列库中富集的 T 细胞表位特异性。
Front Immunol. 2019 Nov 29;10:2820. doi: 10.3389/fimmu.2019.02820. eCollection 2019.
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