Vereshchagin I A, Vereshchagin S I, Zhuravleva O D
Antibiot Med Biotekhnol. 1985 Dec;30(12):927-31.
The course of dysentery and the host immune responsiveness were studied in 171 children with acute Flexner's and Sonne dysentery. 67 children were treated with monomycin in combination with lysozyme and 104 children with monomycin alone. It was shown that the recovery period in children treated with monomycin and lysozyme was shorter as compared to that in children treated with monomycin alone. The immunity characteristics in children treated with monomycin were closer to the physiological values. It is concluded that lysozyme potentiates the antibiotic therapy in children with dysentery. It should be used combined with monomycin in the treatment of children irrespective of the age and the disease pattern. The treatment course with the use of monomycin in combination with lysozyme is reduced to 5 days.
对171例急性弗莱施纳菌痢和宋内菌痢患儿的痢疾病程及宿主免疫反应性进行了研究。67例患儿接受了莫能菌素联合溶菌酶治疗，104例患儿仅接受莫能菌素治疗。结果表明，与仅接受莫能菌素治疗的患儿相比，接受莫能菌素和溶菌酶治疗的患儿恢复期更短。接受莫能菌素治疗的患儿的免疫特征更接近生理值。结论是溶菌酶可增强痢疾患儿的抗生素治疗效果。无论患儿年龄和疾病类型如何，在治疗中均应将其与莫能菌素联合使用。使用莫能菌素联合溶菌酶的治疗疗程缩短至5天。
