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地诺单抗联合微波消融切除术刮除术治疗胸椎巨细胞瘤：1例报告及文献复习

Denosumab combined with microwave ablation excisional scraping for giant cell tumor of the thoracic spine: a case report and literature review.

作者信息

Miao Zukang, Han Zhiwei, Zheng Kai, Xu Ming, Yu Xue, Han Changsheng, Yu Xiuchun

机构信息

Department of Orthopaedic Surgery, The 960th Hospital of the People's Liberation Army Joint Logistics Support Force, Jinan, Shandong, China.

Department of Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

出版信息

Front Oncol. 2024 Sep 19;14:1402550. doi: 10.3389/fonc.2024.1402550. eCollection 2024.

DOI:10.3389/fonc.2024.1402550
PMID:39364313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446914/
Abstract

Denosumab has recently become an important part of the treatment regime for spinal giant cell tumors of the bone (GCTB). Its use has significantly reduced the risk of surgery and postoperative complications in patients with spinal GCTB. However, the use of denosumab has not yet been optimized to reap the maximum benefits. Here, we have reported the case of a patient who was treated with denosumab in combination with excision and scraping for GCTB of the T10 vertebrae, which achieved good tumor control and no recurrence at the 2-year postoperative follow-up. We have also reviewed the case in the light of relevant literature as well as presented our ideas and recommendations for the optimal use of denosumab.

摘要

地诺单抗最近已成为脊柱骨巨细胞瘤（GCTB）治疗方案的重要组成部分。它的使用显著降低了脊柱GCTB患者的手术风险和术后并发症。然而，地诺单抗的使用尚未得到优化以获得最大益处。在此，我们报告了一例T10椎体GCTB患者，采用地诺单抗联合切除和刮除术进行治疗，术后2年随访实现了良好的肿瘤控制且无复发。我们还根据相关文献对该病例进行了回顾，并提出了关于地诺单抗最佳使用的想法和建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/fdd4742fa1ef/fonc-14-1402550-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/a4362a0bbd02/fonc-14-1402550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/1f5837d59cf1/fonc-14-1402550-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/68796d29523b/fonc-14-1402550-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/fdd4742fa1ef/fonc-14-1402550-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/a4362a0bbd02/fonc-14-1402550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/1f5837d59cf1/fonc-14-1402550-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/68796d29523b/fonc-14-1402550-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c24e/11446914/fdd4742fa1ef/fonc-14-1402550-g004.jpg

相似文献

1
Denosumab combined with microwave ablation excisional scraping for giant cell tumor of the thoracic spine: a case report and literature review.地诺单抗联合微波消融切除术刮除术治疗胸椎巨细胞瘤：1例报告及文献复习
Front Oncol. 2024 Sep 19;14:1402550. doi: 10.3389/fonc.2024.1402550. eCollection 2024.
2
Combined preoperative denosumab and adjuvant microwave ablation for high-risk giant cell tumor of bone: a retrospective study in a single center.术前联合地舒单抗与辅助性微波消融治疗高危骨巨细胞瘤：单中心回顾性研究。
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The risk of neurological deterioration while using neoadjuvant denosumab on patients with giant cell tumor of the spine presenting with epidural disease: a meta-analysis of the literature.使用地舒单抗新辅助治疗伴硬膜外疾病的脊柱巨细胞瘤患者时发生神经功能恶化的风险：文献的荟萃分析。
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J Orthop Surg (Hong Kong). 2020 Jan-Apr;28(2):2309499020929786. doi: 10.1177/2309499020929786.
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Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy.新辅助地诺单抗治疗后经全脊椎切除术完全切除的胸椎骨巨细胞瘤
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Short-term Preoperative Denosumab With Surgery in Unresectable or Recurrent Giant Cell Tumor of Bone.术前短期 denosumab 联合手术治疗不可切除或复发性骨巨细胞瘤。
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本文引用的文献

1
The risk of neurological deterioration while using neoadjuvant denosumab on patients with giant cell tumor of the spine presenting with epidural disease: a meta-analysis of the literature.使用地舒单抗新辅助治疗伴硬膜外疾病的脊柱巨细胞瘤患者时发生神经功能恶化的风险：文献的荟萃分析。
Spine J. 2024 Jun;24(6):1056-1064. doi: 10.1016/j.spinee.2024.01.016. Epub 2024 Jan 30.
2
Histological and immunohistochemical analyses of osteoclast maturation in giant cell tumor of bone.骨巨细胞瘤中破骨细胞成熟的组织学和免疫组织化学分析
Pathol Res Pract. 2024 Feb;254:155128. doi: 10.1016/j.prp.2024.155128. Epub 2024 Jan 13.
3
Denosumab combined with precision radiotherapy for recurrent giant cell tumor of the thoracic spine: a case report and literature review.
地诺单抗联合精准放疗治疗复发性胸椎巨细胞瘤：一例报告及文献综述
Front Neurol. 2024 Jan 4;14:1308600. doi: 10.3389/fneur.2023.1308600. eCollection 2023.
4
Efficacy and safety of microwave ablation and its synergistic potential in the treatment of early-stage non-small cell lung cancer.微波消融治疗早期非小细胞肺癌的疗效、安全性及其协同潜力
Clin Imaging. 2024 Mar;107:110070. doi: 10.1016/j.clinimag.2023.110070. Epub 2024 Jan 5.
5
Repercussions of Denosumab in Patients With Giant Cell Tumor of Bone: An Observational Study.地诺单抗对骨巨细胞瘤患者的影响：一项观察性研究。
Cureus. 2023 Nov 12;15(11):e48702. doi: 10.7759/cureus.48702. eCollection 2023 Nov.
6
Current indications for denosumab in benign bone tumours.地诺单抗在良性骨肿瘤中的当前适应证。
EFORT Open Rev. 2023 Dec 1;8(12):895-905. doi: 10.1530/EOR-23-0138.
7
Surgical Strategy for Recurrent Giant Cell Tumor in the Thoracolumbar Spine.胸腰椎复发性巨细胞瘤的手术策略。
Orthop Surg. 2024 Jan;16(1):78-85. doi: 10.1111/os.13911. Epub 2023 Nov 28.
8
Conversion in a Resectable Tumor after Denosumab Neoadjuvant in a Large Dorsal Giant Cells Tumor: A Case Report and a Literature Review.地舒单抗新辅助治疗后可切除肿瘤中的转化：一例大型背侧巨细胞瘤病例报告及文献复习。
Curr Oncol. 2023 Oct 21;30(10):9335-9345. doi: 10.3390/curroncol30100675.
9
The efficacy and safety of short-course neoadjuvant denosumab for en bloc spondylectomy in spinal giant cell tumor of bone: a preliminary report.短程新辅助地舒单抗用于骨巨细胞瘤脊柱整块切除术的疗效和安全性：初步报告。
Eur Spine J. 2023 Dec;32(12):4297-4305. doi: 10.1007/s00586-023-07770-w. Epub 2023 Jun 15.
10
Prevention of Skeletal-Related Events With Extended-Interval Denosumab: A Review of the Literature.延长给药间隔的地诺单抗预防骨相关事件：文献综述
Ann Pharmacother. 2024 Feb;58(2):174-184. doi: 10.1177/10600280231168456. Epub 2023 May 2.