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通过增加支气管内瓣膜治疗来加强对慢性空洞型肺曲霉病的抗真菌治疗。

Enhancing antifungal treatment for chronic cavitary pulmonary aspergillosis through the addition of endobronchial valve therapy.

作者信息

Maitre Thomas, Camuset Juliette, Faure Morgane, Cracco Christophe, Maalouf Georgina, Allenbach Yves, Barral Matthias, Fekkar Arnaud, Giol Mihaela, Parrot Antoine, Cadranel Jacques

机构信息

Service de Pneumologie et d'Oncologie Thoracique et Centre Constitutifs Maladies Pulmonaires Rares, Hôpital Tenon, APHP Sorbonne Université, Paris, France.

Centre d'Immunologie et des Maladies Infectieuses (Cimi Paris), INSERM U1135, Sorbonne Université, Paris, France.

出版信息

Respir Med Case Rep. 2024 Sep 17;52:102106. doi: 10.1016/j.rmcr.2024.102106. eCollection 2024.

DOI:10.1016/j.rmcr.2024.102106
PMID:39364341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11447398/
Abstract

A 62-year-old male experienced -MDA5 dermatomyositis with lung involvement, treated with immunosuppressive therapy leading to chronic cavitary pulmonary aspergillosis in left upper lobe. Patient's history was complicated by complete left pneumothorax due to alveolar-pleural fistula occurring because of the rupture of the pulmonary cavitation. Left lung failed to re-expand despite a four-week period of pleural drainage. In addition to antifungal therapy, patient received endobronchial valve therapy in the anterior segmental bronchus of the left upper lobe leading to air leak cessation, left lung re expansion and aspergillosis cavitation closure.

摘要

一名62岁男性患伴有肺部受累的抗黑色素瘤分化相关基因5（MDA5）皮肌炎，接受免疫抑制治疗后发生左上叶慢性空洞性肺曲霉菌病。患者病史因肺空洞破裂导致肺泡 - 胸膜瘘引发左侧全气胸而变得复杂。尽管进行了为期四周的胸腔引流，左肺仍未能复张。除抗真菌治疗外，患者在左上叶前段支气管接受了支气管内瓣膜治疗，从而停止了漏气，左肺复张且曲霉菌病空洞闭合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11447398/063c6d901b79/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11447398/4dc28369f513/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11447398/a493fc4fd5b7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11447398/063c6d901b79/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11447398/4dc28369f513/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11447398/a493fc4fd5b7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/11447398/063c6d901b79/gr3.jpg

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本文引用的文献

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J Thorac Dis. 2022 Oct;14(10):3876-3885. doi: 10.21037/jtd-22-631.
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Endobronchial Valve Treatment of Tuberculous Cavities in Patients with Multidrug-Resistant Pulmonary Tuberculosis: A Randomized Clinical Study.支气管内瓣膜治疗耐多药肺结核患者的结核空洞：一项随机临床试验
Pathogens. 2022 Aug 10;11(8):899. doi: 10.3390/pathogens11080899.
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Efficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India.
12 个月口服伊曲康唑对比 6 个月口服伊曲康唑预防慢性肺部曲霉病复发的疗效：印度一项开放标签、随机对照试验。
Lancet Infect Dis. 2022 Jul;22(7):1052-1061. doi: 10.1016/S1473-3099(22)00057-3. Epub 2022 Apr 13.
4
Endobronchial valve placement in secondary pneumothorax related to allergic bronchopulmonary aspergillosis.支气管内瓣膜置入治疗与变应性支气管肺曲霉病相关的继发性气胸。
Respir Med Case Rep. 2021 Nov 10;34:101554. doi: 10.1016/j.rmcr.2021.101554. eCollection 2021.
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Chronic pulmonary aspergillosis: prevalence, favouring pulmonary diseases and prognosis.慢性肺曲霉病：患病率、易患肺部疾病和预后。
Eur Respir J. 2021 Aug 19;58(2). doi: 10.1183/13993003.03345-2020. Print 2021 Aug.
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Am J Respir Crit Care Med. 2021 Jan 15;203(2):230-236. doi: 10.1164/rccm.202004-1418OC.
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