生长激素刺激试验期间生长抑素的血浆测定。儿科结果

[Plasma assay of somatocrinin during growth hormone stimulation tests. Results in pediatrics].

作者信息

Evain-Brion D, Donnadieu M, Liapi C, Argente J, Vaudry H, Job J C

出版信息

Arch Fr Pediatr. 1985 Aug-Sep;42 Suppl 1:575-8.

Abstract

Somatocrinin (GHRH) levels were measured by RIA in the plasma of 41 children with constitutionally short stature. Basal plasma GHRH level was 51 +/- 10 pg/ml. L-Dopa induced a two fold increase in circulating GHRH levels 30 to 45 minutes before the elevation of GH. A positive correlation (p less than 0.005) was found between the peak of GH and GHRH levels during the dopaminergic stimulus. Conversely, the secretion of GH induced by amino-acids or clonidine was not preceded by an elevation of GHRH. These results suggest that the various stimulations of GH secretion used for investigations of short stature do not act in the same way at the hypothalamo-pituitary level.

摘要

采用放射免疫分析法（RIA）检测了41例体质性身材矮小儿童血浆中的生长激素释放激素（GHRH）水平。基础血浆GHRH水平为51±10 pg/ml。左旋多巴在生长激素升高前30至45分钟使循环中的GHRH水平升高两倍。在多巴胺能刺激期间，生长激素峰值与GHRH水平之间发现正相关（p<0.005）。相反，氨基酸或可乐定诱导的生长激素分泌之前，GHRH并没有升高。这些结果表明，用于身材矮小研究的各种生长激素分泌刺激在下丘脑-垂体水平的作用方式不同。