Maresz-Babczyszyn J, Lagowska-Złotorzycka M, Czarny A
Arch Immunol Ther Exp (Warsz). 1985;33(4):507-13.
High doses of slime-extract from Pseudomonas aeruginosa was found to suppress the delayed type hypersensitivity response to sheep erythrocytes when administered intraperitoneally 1 to 3 days before or 3 days after intravenous sensitization of mice. Moreover, the spleen cells from sensitized and slime-extract treated mice transferred the depression to normal recipients. Inhibition of DTH response was also seen when recipients were injected with slime-extract 24 h before they were infused with spleen cells from donor mice immunized with sheep erythrocytes. The development of skin DTH was quantitated by footpad increase. The data suggest that slime-extract from P. aeruginosa induces in spleens of mice immunosuppressive cells which affect the immunization with sheep red blood cells.
当在小鼠静脉致敏前1至3天或致敏后3天腹腔注射高剂量铜绿假单胞菌的黏液提取物时，发现其可抑制对绵羊红细胞的迟发型超敏反应。此外，来自致敏且经黏液提取物处理的小鼠的脾细胞可将这种抑制作用传递给正常受体。当在受体小鼠注入用绵羊红细胞免疫的供体小鼠的脾细胞前24小时注射黏液提取物时，也观察到迟发型超敏反应受到抑制。通过足垫肿胀来定量皮肤迟发型超敏反应的发展。数据表明，铜绿假单胞菌的黏液提取物在小鼠脾脏中诱导产生免疫抑制细胞，这些细胞会影响对绵羊红细胞的免疫。
