Zhang Yanjun, Zhou Chun, Ye Ziliang, Liu Mengyi, He Panpan, Yang Sisi, Zhang Yuanyuan, Gan Xiaoqin, Qin Xianhui
Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515, China.
J Clin Endocrinol Metab. 2024 Oct 4. doi: 10.1210/clinem/dgae692.
The association of serum 25-hydroxyvitamin D [25(OH)D] and genetic polymorphisms of the vitamin D receptor (VDR), and the vitamin D binding protein (VDBP) with incident abdominal aortic aneurysm (AAA) remains uncertain.
To investigate whether serum 25(OH)D, genetic polymorphisms of VDR and VDBP, genetic susceptibility to AAA, and the interactions among these factors influence the risk of incident AAA.
Retrospective cohort study.
UK Biobank.
447,529 participants without a diagnosis of prevalent aortic aneurysm or aortic dissection at baseline.
Serum 25(OH)D concentration.
Incident AAA.
During a median follow-up of 12.5 years, 2,042 participants developed incident AAA. A significant inverse association between serum 25(OH)D and incident AAA was observed (per SD increment, HR, 0.92; 95%CI, 0.88-0.96), which was particularly pronounced in older individuals and those without diabetes (both P for interaction <0.05). Compared to participants with serum 25(OH)D ≥ 50 nmol/L, those with serum 25(OH)D between 25 and <50 nmol/L and <25 nmol/L exhibited a significant higher risk of incident AAA. In the 371,621 participants with genetics assessment, individuals carrying AA alleles of ApaI SNP had a significant increased risk of incident AAA compared to those carrying CC alleles (HR, 1.16; 95%CI, 1.02-1.32). The inverse association between serum 25(OH)D and incident AAA was stronger in individuals with intermediate or high genetic risk for AAA (P for interaction = 0.048).
There was a significant inverse association between serum 25(OH)D and AAA incidence, particularly among individuals with higher genetic risk for AAA, older age, and without diabetics.
血清25-羟基维生素D[25(OH)D]、维生素D受体（VDR）和维生素D结合蛋白（VDBP）的基因多态性与腹主动脉瘤（AAA）发病之间的关联尚不确定。
探讨血清25(OH)D、VDR和VDBP的基因多态性、AAA的遗传易感性以及这些因素之间的相互作用是否会影响AAA发病风险。
回顾性队列研究。
英国生物银行。
447,529名在基线时未诊断出患有主动脉瘤或主动脉夹层的参与者。
血清25(OH)D浓度。
新发AAA。
在中位随访12.5年期间，2,042名参与者发生了新发AAA。观察到血清25(OH)D与新发AAA之间存在显著的负相关（每标准差增加，HR为0.92；95%CI为0.88-0.96），在老年人和无糖尿病患者中尤为明显（交互作用P值均<0.05）。与血清25(OH)D≥50 nmol/L的参与者相比，血清25(OH)D在25至<50 nmol/L和<25 nmol/L之间的参与者发生新发AAA的风险显著更高。在371,621名进行了基因评估的参与者中，携带ApaI SNP的AA等位基因的个体与携带CC等位基因的个体相比，发生新发AAA的风险显著增加（HR为1.16；95%CI为1.02-1.32）。血清25(OH)D与新发AAA之间的负相关在AAA遗传风险为中度或高度的个体中更强（交互作用P值=0.048）。
血清25(OH)D与AAA发病率之间存在显著的负相关，尤其是在AAA遗传风险较高、年龄较大且无糖尿病的个体中。
